Title: Role of endogenous PGE2 in liver repair after hepatic ischemia/reperfusion
Abstract: Background: Hepatic ischemia/reperfusion (I/R) injury is a major adverse reaction to liver surgery. Impaired liver repair following hepatic I/R affects the outcome of the patients. This study aims to examine the role of endogenous PGE2 produced by inducible microsomal PGE synthase-1 (mPGES-1), a terminal enzyme of PGE2 generation, in liver repair following hepatic I/R.