Title: Two pools for amines in neoplastic mast cells
Abstract: The distribution of endogenous and exogenous 5-hydroxytryptamine and histamine was determined in neoplastic mast cells growing in culture. In cells containing measurable amounts of these endogenous amines, most of the exogenous amines were found in intracellular fractions almost devoid of endogenous amines. In cells in which these endogenous amines could not be detected, the exogenous amines were found in the particulate material in which endogenous amines are normally present. It is suggested that the endogenous amines are held in a pool separate from the exogenous amines and that the accesibility of the exogenous amines to the pool for endogenous amines is a function of the levels of endogenous amines already existing in the pool.
Publication Year: 1962
Publication Date: 1962-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 35
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