Title: Effect and mechanisms of action of Siliankang as an adjuvant therapy for ulcerative colitis.
Abstract: Objective To research the effect of Siliankang as an adjuvant therapy for ulcerative colitis and its mechanisms of action.Method The patients with ulcerative colitis were randomized into experiment group and control group.The patients in experiment group were treated with Siliankang and routine treatment,while the patients in contorl group received only routine treatment.The clinical symptom score,colon mucosa inflammation,levels of IL-10,IL-18 in serum were compared between two groups before treatment and two months after treatment.Result There were no difference between the clinical symptom score and colonic mucosal inflammation score of two groups before treatment.Two months after treatment,the clinical symptom score and colonic mucosal inflammation score descended significantly(P0.01),especially in experiment group(P0.01).The average serum level of IL-10 was significantly increased,especially in experiment group(P0.01).The average serum level of IL-18 was significantly descended,especially in experiment group(P0.01).Conclusion The adjuvant curative effect of Siliankang on ulcerative colitis could be related to impact on IL-10 and IL-18.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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