Publication Information

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3954], 'DataTransparent': [5], 'process': [6, 674], 'Amyloid': [7, 900, 913, 924], 'aggregates': [8, 901, 914, 1901, 2624, 3209, 3239, 3345, 4053, 4120, 4136, 4160, 4203], 'accumulate': [9, 4022, 4204], 'in': [10, 766, 790, 793, 800, 815, 875, 904, 978, 1019, 1120, 1125, 1147, 1195, 1261, 1366, 1381, 1408, 1425, 1591, 1855, 1902, 1906, 1913, 1990, 2152, 2166, 2173, 2226, 2250, 2259, 2285, 2338, 2396, 2433, 2519, 2601, 2625, 2642, 2657, 2670, 2718, 2762, 2773, 2804, 2944, 2962, 2982, 2992, 3041, 3047, 3073, 3086, 3095, 3104, 3147, 3157, 3163, 3189, 3201, 3210, 3241, 3264, 3269, 3294, 3347, 3361, 3386, 3410, 3432, 3554, 3568, 3572, 3648, 3663, 3695, 3704, 3715, 3720, 3730, 3742, 3766, 3777, 3783, 3790, 3813, 3822, 3837, 3882, 3910, 3973, 3994, 4001, 4006, 4023, 4041, 4057, 4122, 4132, 4143, 4163, 4205, 4232, 4238], 'melanoma': [11, 731, 802, 854, 878, 957, 988, 1151, 1172, 1206, 1293, 1315, 1455, 1476, 1500, 1703, 1710, 1717, 1955, 2376, 2817, 2828, 2906, 3028, 3037, 3069, 3131, 3142, 3200, 3245, 3251, 3265, 3297, 3305, 3317, 3353, 3384, 3414, 3417, 3476, 3544, 3569, 3653, 3705, 3717, 3747, 3817, 3826, 3841, 3893, 3975, 4027, 4046, 4058, 4165, 4193, 4208, 4230, 4236], 'metastasis': [12], 'modulating': [13], 'YAP': [14, 818, 833, 881, 919], 'activity': [15, 705], 'Vittoria': [16, 18, 286, 288, 558], 'Matafora': [17, 19, 287, 289], 'orcid.org/0000-0002-4311-998X': [20, 290], 'IFOM-': [21, 41, 60, 79, 98, 117, 136, 160, 185, 204, 223, 271, 291, 311, 330, 349, 368, 387, 406, 430, 455, 474, 493, 541], 'FIRC': [22, 42, 61, 80, 99, 118, 137, 161, 186, 205, 224, 272, 292, 312, 331, 350, 369, 388, 407, 431, 456, 475, 494, 542, 587], 'Institute': [23, 43, 62, 81, 100, 119, 138, 162, 187, 206, 225, 273, 293, 313, 332, 351, 370, 389, 408, 432, 457, 476, 495, 543, 588, 633], 'of': [24, 44, 63, 82, 101, 120, 139, 145, 163, 188, 207, 226, 243, 247, 274, 294, 314, 333, 352, 371, 390, 409, 415, 433, 458, 477, 496, 513, 517, 544, 589, 595, 606, 610, 629, 634, 660, 670, 727, 759, 783, 811, 851, 859, 872, 907, 918, 949, 962, 971, 1003, 1022, 1048, 1065, 1076, 1094, 1112, 1161, 1182, 1215, 1256, 1300, 1411, 1434, 1472, 1489, 1498, 1627, 1676, 1695, 1706, 1716, 1725, 1746, 1758, 1763, 1787, 1803, 1819, 1824, 1841, 1852, 1867, 1879, 1900, 1910, 1940, 1946, 1954, 1962, 2033, 2039, 2050, 2060, 2071, 2137, 2159, 2201, 2268, 2297, 2369, 2381, 2391, 2399, 2428, 2436, 2466, 2493, 2501, 2517, 2530, 2622, 2632, 2705, 2725, 2745, 2759, 2797, 2835, 2847, 2886, 3001, 3021, 3033, 3062, 3077, 3110, 3116, 3124, 3207, 3250, 3343, 3350, 3358, 3383, 3463, 3543, 3582, 3594, 3620, 3625, 3651, 3689, 3692, 3702, 3746, 3774, 3780, 3804, 3832, 3865, 3871, 3880, 3885, 3900, 3940, 3943, 3969, 3989, 4026, 4044, 4118, 4158, 4170, 4226, 4247], 'Molecular': [25, 45, 64, 83, 102, 121, 140, 164, 189, 208, 227, 275, 295, 315, 334, 353, 372, 391, 410, 434, 459, 478, 497, 545, 590], 'Oncology,': [26, 46, 65, 84, 103, 122, 141, 165, 190, 209, 228, 276, 296, 316, 335, 354, 373, 392, 411, 435, 460, 479, 498, 546, 591, 631], 'Milan,': [27, 47, 66, 85, 104, 123, 142, 166, 172, 191, 210, 229, 253, 277, 297, 317, 336, 355, 374, 393, 412, 436, 442, 461, 480, 499, 523, 547, 592, 603, 616, 637, 645], 'Italy': [28, 48, 67, 86, 105, 124, 143, 148, 167, 173, 192, 211, 230, 254, 278, 298, 318, 337, 356, 375, 394, 413, 418, 437, 443, 462, 481, 500, 524, 548, 593, 598, 604, 617, 625, 638, 646], 'Search': [29, 49, 68, 87, 106, 125, 149, 174, 193, 212, 231, 255, 279, 299, 319, 338, 357, 376, 395, 419, 444, 463, 482, 501, 525, 549], 'for': [30, 50, 69, 88, 107, 126, 150, 175, 194, 213, 232, 256, 280, 300, 320, 339, 358, 377, 396, 420, 445, 464, 483, 502, 526, 550, 853, 866, 897, 960, 968, 990, 1292, 1389, 1431, 1684, 1690, 1699, 1791, 1888, 2047, 2230, 2702, 3262, 3288, 3301, 3475, 3557, 3951, 3956], 'more': [31, 51, 70, 89, 108, 127, 151, 176, 195, 214, 233, 257, 281, 301, 321, 340, 359, 378, 397, 421, 446, 465, 484, 503, 527, 551, 1235, 3713], 'papers': [32, 52, 71, 90, 109, 128, 152, 177, 196, 215, 234, 258, 282, 302, 322, 341, 360, 379, 398, 422, 447, 466, 485, 504, 528, 552], 'by': [33, 53, 72, 91, 110, 129, 153, 178, 197, 216, 235, 259, 283, 303, 323, 342, 361, 380, 399, 423, 448, 467, 486, 505, 529, 553, 707, 720, 1135, 1175, 1185, 1268, 1358, 1457, 1765, 1834, 1858, 1873, 1966, 2056, 2155, 2471, 2523, 2680, 2883, 3129, 3199, 3255, 3429, 3438, 3514, 3526, 3672, 3679, 3792, 3977, 4099, 4196], 'this': [34, 54, 73, 92, 111, 130, 154, 179, 198, 217, 236, 260, 284, 304, 324, 343, 362, 381, 400, 424, 449, 468, 487, 506, 530, 554, 743, 1355, 1396, 1776, 2090, 2733, 3011, 3048, 3225, 3952, 4062], 'author': [35, 55, 74, 93, 112, 131, 155, 180, 199, 218, 237, 261, 285, 305, 325, 344, 363, 382, 401, 425, 450, 469, 488, 507, 531, 555, 682], 'Francesco': [36, 38, 306, 308, 560], 'Farris': [37, 39, 307, 309], 'orcid.org/0000-0003-0565-484X': [40, 310], 'Umberto': [56, 58, 326, 328, 562], 'Restuccia': [57, 59, 327, 329], 'Simone': [75, 77, 345, 347, 564], 'Tamburri': [76, 78, 346, 348], 'Giuseppe': [94, 96, 364, 366, 566], 'Martano': [95, 97, 365, 367], 'Clara': [113, 115, 383, 385, 568], 'Bernardelli': [114, 116, 384, 386], 'Andrea': [132, 134, 402, 404, 570], 'Sofia': [133, 135, 403, 405], 'University': [144, 414], 'Insubria,': [146, 416, 596], 'Varese,': [147, 417, 597], 'Federica': [156, 158, 426, 428, 572], 'Pisati': [157, 159, 427, 429], 'Cogentech': [168, 438], 'SRL': [169, 439, 600], 'Benefit': [170, 440, 601], 'Corporation,': [171, 441, 602], 'Francesca': [181, 183, 451, 453, 574], 'Casagrande': [182, 184, 452, 454], 'Luca': [200, 202, 470, 472, 576], 'Lazzari': [201, 203, 471, 473], 'Silvia': [219, 221, 489, 491, 578], 'Marsoni': [220, 222, 490, 492], 'Emanuela': [238, 240, 508, 510, 580], 'Bonoldi': [239, 241, 509, 511], 'Department': [242, 512, 628], 'Laboratory': [244, 514, 607], 'Medicine,': [245, 515, 608], 'Division': [246, 516, 609], 'Pathology,': [248, 518, 611], 'Grande': [249, 519, 612], 'Ospedale': [250, 520, 613], 'Metropolitano': [251, 521, 614], 'Niguarda,': [252, 522, 615], 'Angela': [262, 266, 532, 536, 583], 'Bachi': [263, 267, 533, 537, 584], 'Corresponding': [264, 534], 'Author': [265, 535, 556], '[email': [268, 538, 653], 'protected]': [269, 539, 654], 'orcid.org/0000-0003-4842-6556': [270, 540], 'Information': [557], 'Matafora1,': [559], 'Farris1,': [561], 'Restuccia1,5,': [563], 'Tamburri1,6,': [565], 'Martano1,': [567], 'Bernardelli1,7,': [569], 'Sofia1,2,': [571], 'Pisati1,3,': [573], 'Casagrande1,': [575], 'Lazzari1,': [577], 'Marsoni1,': [579], 'Bonoldi4': [581], 'and': [582, 663, 681, 733, 741, 844, 856, 890, 920, 933, 947, 995, 1015, 1055, 1142, 1179, 1227, 1250, 1311, 1362, 1377, 1385, 1402, 1474, 1491, 1506, 1513, 1527, 1538, 1571, 1588, 1629, 1655, 1686, 1701, 1708, 1728, 1748, 1760, 1784, 1793, 1797, 1806, 1826, 1839, 1843, 1869, 1884, 1890, 1969, 1971, 1975, 2008, 2015, 2066, 2089, 2143, 2148, 2170, 2191, 2207, 2229, 2276, 2280, 2329, 2352, 2374, 2393, 2402, 2416, 2430, 2439, 2453, 2474, 2483, 2506, 2584, 2592, 2637, 2649, 2682, 2747, 2772, 2779, 2782, 2810, 2860, 2914, 2924, 2929, 2955, 2957, 2977, 2995, 3026, 3052, 3098, 3196, 3233, 3237, 3258, 3313, 3325, 3415, 3435, 3453, 3485, 3517, 3565, 3592, 3643, 3681, 3691, 3710, 3794, 3815, 3819, 3824, 3835, 3839, 3874, 3876, 3889, 3906, 3912, 3924, 3933, 4004, 4010, 4071, 4083, 4091, 4097, 4107, 4175, 4180, 4215, 4234], '*,1': [585], '1IFOM-': [586], '2University': [594], '3Cogentech': [599], '4Department': [605], '5Present': [618], 'address:': [619, 627, 640], 'ADIENNE': [620], 'Pharma': [621], '&': [622, 694, 953], 'Biotech,': [623], 'Caponago,': [624], '6Present': [626], 'Experimental': [630], 'IEO-European': [632], 'Oncology': [635], 'IRCCS,': [636], '7Present': [639], 'Fondazione': [641], 'Politecnico': [642], 'di': [643], 'Milano,': [644], '*Corresponding': [647], 'author.': [648], 'Tel:': [649], '+39': [650], '02574303873;': [651], 'E-mail:': [652], 'EMBO': [655], 'Reports': [656], '(2020)21:e50446https://doi.org/10.15252/embr.202050446': [657], 'PDFDownload': [658], 'PDF': [659], 'article': [661], 'text': [662], 'main': [664, 1110, 3088], 'figures.': [665], 'Peer': [666], 'ReviewDownload': [667], 'a': [668, 1088, 1257, 1274, 1346, 1367, 1567, 1606, 1611, 1677, 1696, 1788, 1862, 1959, 1996, 2102, 2113, 2294, 2608, 2655, 2737, 2798, 2872, 3202, 3502, 3761, 3883, 4113, 4154], 'summary': [669], 'the': [671, 708, 715, 725, 756, 781, 809, 849, 857, 876, 905, 938, 945, 969, 982, 1011, 1036, 1063, 1080, 1092, 1148, 1159, 1162, 1180, 1254, 1298, 1337, 1409, 1412, 1417, 1427, 1432, 1461, 1478, 1482, 1520, 1543, 1580, 1597, 1635, 1856, 1903, 1914, 1951, 1963, 1987, 1991, 2003, 2026, 2048, 2058, 2061, 2134, 2167, 2174, 2180, 2202, 2209, 2266, 2298, 2355, 2360, 2370, 2397, 2434, 2467, 2481, 2494, 2597, 2620, 2630, 2703, 2712, 2719, 2723, 2763, 2774, 2795, 2805, 2849, 2894, 2937, 2946, 2964, 2999, 3022, 3078, 3087, 3117, 3125, 3140, 3154, 3164, 3173, 3180, 3211, 3279, 3289, 3295, 3348, 3362, 3471, 3482, 3486, 3490, 3510, 3522, 3540, 3558, 3649, 3659, 3687, 3700, 3727, 3743, 3752, 3772, 3778, 3802, 3938, 3967, 3986, 3990, 4011, 4016, 4031, 4042, 4123, 4141, 4148, 4185], 'editorial': [672, 676], 'decision': [673, 677], 'including': [675], 'letters,': [678], 'reviewer': [679], 'comments': [680], 'responses': [683], 'to': [684, 687, 787, 829, 910, 1170, 1189, 1192, 1197, 1212, 1232, 1246, 1251, 1253, 1344, 1354, 1452, 1480, 1574, 1579, 1614, 1774, 1781, 1861, 2036, 2120, 2127, 2183, 2214, 2246, 2287, 2313, 2350, 2566, 2653, 2698, 2794, 3009, 3016, 3223, 3230, 3500, 3669, 3685, 3787, 3936, 4015, 4191], 'feedback.': [685], 'ToolsAdd': [686], 'favoritesDownload': [688], 'CitationsTrack': [689], 'CitationsPermissions': [690], 'ShareFacebookTwitterLinked': [691], 'InMendeleyWechatReddit': [692], 'Figures': [693], 'Info': [695], 'Abstract': [696], 'Melanoma': [697, 936, 1128, 1350], 'progression': [698, 732, 4188], 'is': [699, 744, 746, 937, 966, 1013, 1017, 1069, 1096, 1114, 1173, 1375, 1387, 1753, 1895, 2512, 2596, 2607, 2613, 2677, 3368, 3403, 3422, 3536, 3658, 3667, 3677, 3916, 3998, 4194, 4242], 'generally': [700], 'associated': [701, 3538], 'with': [702, 770, 975, 1605, 1610, 1643, 1917, 2013, 2124, 2140, 2340, 2412, 2421, 2449, 2458, 2534, 2640, 2685, 2789, 2863, 2901, 2970, 2989, 3081, 3179, 3217, 3365, 3390, 3393, 3507, 3519, 3539, 3587, 3629, 3755, 3929, 4095, 4212], 'increased': [703, 1176, 1572, 4197], 'transcriptional': [704, 922], 'mediated': [706, 2679], 'Yes-associated': [709], 'protein': [710, 764, 2097, 2121, 2129, 2271, 2623, 2738, 2812, 2890, 2916, 3190, 3208, 3238, 3344, 3662, 4052, 4119, 4135, 4159], '(YAP).': [711], 'Mechanical': [712], 'signals': [713, 738], 'from': [714, 944, 1044, 1297, 1400, 1510, 1519, 1534, 1542, 1664, 1993, 2006, 2053, 2372, 2839, 2857, 2879, 3024, 3278, 3562, 4030, 4068, 4079, 4189], 'extracellular': [716, 737, 757, 1216, 1265, 1904, 2720, 2775, 2801], 'matrix': [717, 1139, 1217, 1270, 1276, 1466, 2315], 'are': [718, 827, 902, 1005, 1210, 1422, 1739, 1930, 2086, 2337, 2348, 2550, 2696, 2814, 3056, 3335, 3376, 3512, 3524, 3646, 3856, 3948, 4054], 'sensed': [719], 'YAP,': [721], 'which': [722, 814, 1059, 1068, 1117, 1230, 3676], 'then': [723, 3965], 'activates': [724], 'expression': [726, 3236, 3276, 3286, 3427, 3445, 3462, 3508, 3520, 3530, 3548, 3782, 3821], 'proliferative': [728, 1678], 'genes,': [729], 'promoting': [730], 'drug': [734, 846], 'resistance.': [735], 'Which': [736], 'induce': [739, 817, 830, 915], 'mechanotransduction,': [740, 831], 'how': [742, 1371, 1378], 'mediated,': [745], 'not': [747, 1328, 4005], 'completely': [748], 'understood.': [749], 'Here,': [750], 'using': [751, 1648, 1846, 2871, 3439, 3470, 3981], 'secretome': [752, 906, 1398, 1458, 1857, 2289, 2371, 2398, 2435, 2821, 3023, 3182, 3349, 3650, 4043], 'analyses,': [753], 'we': [754, 836, 1494, 1957, 2024, 2067, 2099, 2162, 2645, 2735, 2919, 3184, 3698, 4049, 4064, 4111], 'reveal': [755], 'accumulation': [758, 782, 871], 'amyloidogenic': [760, 3971], 'proteins,': [761, 2714, 2791, 2940], 'i.e.': [762, 2729], 'premelanosome': [763], '(PMEL),': [765], 'metastatic': [767, 794, 867, 877, 887, 898, 908, 930, 1149, 1171, 1473, 1490, 1665, 1702, 1729, 1794, 1807, 2009, 2375, 2403, 2440, 2482, 2603, 2643, 2806, 2827, 2923, 2965, 2984, 3027, 3096, 3165, 3212, 3244, 3316, 3416, 3652, 3664, 3696, 3716, 3767, 3784, 3816, 3840, 3890, 3974, 4002, 4024, 4045, 4086, 4108, 4164, 4192, 4207], 'melanoma,': [768, 1795, 3697, 3785], 'together': [769, 2788, 2988], 'proteins': [771, 1853, 1911, 1942, 1964, 1982, 2004, 2042, 2051, 2085, 2139, 2165, 2172, 2243, 2301, 2311, 2336, 2395, 2408, 2420, 2432, 2445, 2457, 2469, 2532, 2564, 2586, 2600, 2651, 2761, 2895, 2959, 2990, 2997, 3080, 3093, 3102, 3112, 3127, 3155, 3187, 3359, 3645, 4021, 4036, 4198], 'that': [772, 823, 838, 1087, 1155, 1324, 1485, 1661, 1983, 2069, 2074, 2409, 2446, 2823, 2896, 3984, 4033, 4187], 'assist': [773], 'amyloid': [774, 2694, 2786, 3002, 3158, 3807], 'maturation': [775, 810, 2674, 2687, 3160, 3803], 'into': [776, 1091, 2675, 3806], 'fibrils.': [777, 3808], 'We': [778, 820, 1449, 2001, 2045, 2709, 2892, 3964], 'also': [779, 821, 1287, 1335, 1594, 2618, 2678, 3170, 3741, 4056], 'confirm': [780], 'amyloid-like': [784, 4034], 'aggregates,': [785, 813], 'similar': [786, 3941], 'those': [788], 'detected': [789, 1833, 4112, 4162], 'Alzheimer': [791, 2626], 'disease,': [792, 1030], 'cell': [795, 842, 888, 931, 1177, 1501, 1530, 1555, 1564, 1584, 1600, 1711, 1731, 1809, 1828, 1836, 2010, 2062, 2307, 2476, 2521, 2560, 2572, 2604, 2750, 2768, 2807, 2818, 2836, 2850, 2948, 2966, 2986, 3038, 3070, 3118, 3132, 3143, 3166, 3203, 3213, 3246, 3298, 3306, 3318, 3354, 3584, 3613, 3732, 3827, 3894, 4047], 'lines,': [796, 3516, 4048], 'as': [797, 799, 862, 895, 1220, 1289, 1302, 1817, 2043, 2083, 2344, 2700, 3193, 3337, 3418, 3596, 3843], 'well': [798], 'human': [801, 3387, 4206, 4221], 'biopsies.': [803], 'Mechanistically,': [804], 'beta-secretase': [805, 860, 893], '2': [806], '(BACE2)': [807], 'regulates': [808], 'these': [812, 1077, 1304, 1554, 1658, 3737], 'turn': [816], 'activity.': [819, 882, 923], 'demonstrate': [822, 837], 'recombinant': [824], 'PMEL': [825, 873, 2673, 2693, 2715, 3644, 3805, 3820, 3902, 3931, 3970, 3997], 'fibrils': [826, 874, 2676, 2695, 3159], 'sufficient': [828], 'triggering': [832], 'signaling.': [834], 'Finally,': [835], 'BACE': [839, 3272], 'inhibition': [840, 894, 928, 3273], 'affects': [841, 929], 'proliferation': [843, 889, 932, 948, 1278], 'increases': [845, 1277], 'sensitivity,': [847], 'highlighting': [848, 2722], 'importance': [850], 'amyloids': [852], 'survival,': [855], 'use': [858], 'inhibitors': [861, 1054, 1326], 'potential': [863], 'therapeutic': [864, 1037], 'approach': [865], 'melanoma.': [868, 899, 912, 3768], 'Synopsis': [869], 'The': [870, 1109, 2820, 2844, 3395, 3443, 3478, 3609, 3615], 'microenvironment': [879, 1238, 1357, 1383, 1456, 1488, 1948], 'modulates': [880], 'Preventing': [883], 'aggregate': [884], 'formation': [885, 2621, 2727, 2796], 'reduces': [886], 'chemosensitivity,': [891], 'suggesting': [892], 'treatment': [896, 1393], 'enriched': [903, 2647, 2717, 3162, 3171, 4039], 'compared': [909, 1578, 1642, 1860, 2182, 2213], 'primary': [911, 2611, 3105], 'nuclear': [916], 'localization': [917, 4172], 'its': [921], 'impairment': [925], 'through': [926, 2354, 2359, 2629], 'BACE2': [927, 3263, 3426, 3529], 'chemosensitivity.': [934], 'Introduction': [935], 'most': [939, 2598, 3660], 'aggressive': [940], 'cutaneous': [941, 1535], 'cancer,': [942], 'resulting': [943], 'transformation': [946], 'skin': [950, 963, 972, 1539, 4080], 'melanocytes': [951], '(Shain': [952], 'Bastian,': [954], '2016).': [955], 'While': [956], 'only': [958, 1329, 2293], 'accounts': [959, 989], '1%': [961], 'cancers,': [964, 1263], 'it': [965, 1379, 2617], 'responsible': [967], 'majority': [970], 'cancer': [973, 1372, 1392, 3256, 3430], 'deaths': [974], 'an': [976, 1045, 1097, 1233, 1264, 1687, 2157, 2757, 3982], 'incidence': [977], 'rapid': [979, 1576], 'increase': [980, 2128], 'over': [981], 'past': [983], '30': [984, 4243], 'years.': [985], 'In': [986, 1395, 1469, 1503, 1560, 2968, 3683, 4104], 'Europe,': [987], 'about': [991, 2199], '150,000': [992], 'new': [993, 1049, 1356], 'cases': [994, 1023, 1078], '27,147': [996], 'deaths/year': [997], '(Globocan': [998], '2018,': [999], 'https://gco.iarc.fr/today/fact-sheets-populations).': [1000], 'Approximately': [1001], '85%': [1002], 'melanomas': [1004, 1095], 'diagnosed': [1006], 'at': [1007, 3172, 3398, 3589], 'early': [1008], 'stages': [1009], 'when': [1010, 1645], 'tumor': [1012, 1186, 1208, 1237, 1309, 1332, 1339, 1382, 1401, 1418, 1454, 1487, 1512, 1537, 1947, 2346, 2985, 3449, 3722, 4109, 4127, 4149], 'thin': [1014], 'surgery': [1016], 'curative': [1018], '>': [1020, 2077], '95%': [1021, 3491], '(American': [1024], 'Cancer': [1025, 3149, 3280], 'Society,': [1026], 'www.cancer.org).': [1027], 'For': [1028, 2021], 'advanced': [1029, 1066], 'either': [1031, 2882], 'unresectable': [1032], 'or': [1033, 1124, 2358, 2888, 3392, 4115], 'already': [1034], 'metastatic,': [1035], 'landscape': [1038], 'has': [1039], 'benefitted': [1040], 'since': [1041, 1420], 'few': [1042], 'years': [1043], 'unprecedented': [1046], 'number': [1047, 1626, 1818, 1840, 2267, 2885], 'drugs': [1050], '(e.g.': [1051], 'immune': [1052, 1163], 'checkpoint': [1053], 'small-molecule': [1056], 'targeted': [1057], 'drugs)': [1058], 'have': [1060, 2654, 2908], 'significantly': [1061, 2899], 'improved': [1062], 'prognosis': [1064], 'patient': [1067, 1547], 'otherwise': [1070], 'dismal.': [1071], 'That': [1072], 'notwithstanding,': [1073], '<': [1074, 1922, 2414, 2423, 2451, 2460, 2542, 3329, 3332, 3373, 3496, 3577, 3604, 3607, 3848], '30%': [1075], 'reaches': [1079], '5-year': [1081], 'landmark': [1082], 'disease': [1083, 1313, 2627], 'free,': [1084], 'clearly': [1085], 'indicating': [1086, 3760], 'deeper': [1089], 'insight': [1090], 'biology': [1093], 'unmet': [1098], 'clinical': [1099], 'need': [1100], '(Guy': [1101], 'et': [1102, 1106, 1166, 1202, 1224, 1240, 1280, 1318, 1438, 1442, 1446, 1681, 2218, 2662, 2666, 2690, 3797], 'al,': [1103, 1107, 1167, 1203, 1225, 1241, 1281, 1319, 1439, 1443, 1447, 1682, 2219, 2663, 2667, 2691, 3798], '2015;': [1104], 'Pasquali': [1105], '2018).': [1108, 2220], 'cause': [1111], 'death': [1113], 'widespread': [1115], 'metastases,': [1116], 'commonly': [1118, 1622], 'develop': [1119, 1153], 'regional': [1121], 'lymph': [1122, 1514], 'nodes': [1123], 'distant': [1126], 'organs.': [1127], 'cells': [1129, 1152, 1209, 1333, 1351, 1404, 1415, 1662, 1718, 1845, 1977, 2055, 2264, 2347, 2377, 2887, 2907, 3029, 3718, 3818, 3842, 3976, 4003], 'travel': [1130], 'along': [1131, 4140], 'external': [1132], 'vessel': [1133], 'lattices': [1134], 'regulating': [1136], 'adhesion': [1137, 1199, 2573], 'molecules,': [1138], 'metalloproteases,': [1140], 'chemokines,': [1141], 'growth': [1143, 1310, 1569, 2864], 'factors.': [1144], 'After': [1145], 'steadied': [1146], 'sites,': [1150], 'mechanisms': [1154], 'protect': [1156], 'them': [1157, 1296, 1343, 2072], 'against': [1158], 'attack': [1160], 'system': [1164, 1698, 1790], '(Zbytek': [1165], '2008).': [1168], 'Progression': [1169], 'accompanied': [1174, 4195], 'stiffness': [1178, 1194], 'acquisition': [1181, 1255, 3382], 'higher': [1183, 1625, 1640, 4156], 'plasticity': [1184], 'cells,': [1187, 1294, 2161, 2672, 3097, 3723, 3748], 'due': [1188], 'their': [1190, 1551, 2341, 4007], 'ability': [1191, 1573], 'control': [1193, 1247], 'response': [1196], 'diverse': [1198], 'conditions': [1200], '(Weder': [1201], '2014).': [1204, 2668], 'During': [1205], 'development,': [1207], 'exposed': [1211], 'various': [1213], 'types': [1214], '(ECM)': [1218], 'such': [1219, 3192], 'tenascin-C,': [1221], 'fibronectin': [1222], '(Frey': [1223], '2011),': [1226], 'collagen': [1228], 'fibers': [1229], 'led': [1231], 'overall': [1234, 3259, 3541], 'rigid': [1236], '(Yu': [1239], '2011).': [1242], 'Stiffness': [1243], 'was': [1244, 1322, 1999, 2117, 2257, 2272, 2829, 2869, 3215, 3292, 3498, 4161], 'suggested': [1245], 'phenotypic': [1248], 'states': [1249], 'contribute': [1252, 2793], 'malignant': [1258, 1465], 'phenotype.': [1259], 'Indeed,': [1260, 3707], 'epithelial': [1262], 'environment': [1266, 2802], 'characterized': [1267], 'softer': [1269], 'enables': [1271, 2133], 'differentiation,': [1272], 'while': [1273, 1617, 3315], 'stiffer': [1275], '(Lee': [1279], '2017).': [1282], 'Increased': [1283], 'ECM': [1284, 1360, 1374, 2314, 2567, 2993], 'rigidity': [1285], 'might': [1286, 2092], 'serve': [1288, 2699], '"safe': [1290], 'haven"': [1291], 'protecting': [1295], 'effects': [1299], 'chemotherapy;': [1301], 'such,': [1303], 'drug-induced': [1305], 'biomechanical': [1306], 'niches': [1307, 1436], 'foster': [1308], 'residual': [1312], 'favoring': [1314], 'resistance': [1316], '(Hirata': [1317], '2015).': [1320, 2692], 'It': [1321], 'observed': [1323, 2920], 'BRAF': [1325, 3053], 'do': [1327], 'act': [1330], 'on': [1331, 1336, 2832, 2876, 3036, 3922, 4219], 'but': [1334, 1669, 2616], 'neighboring': [1338], 'fibroblasts,': [1340], 'paradoxically': [1341], 'activating': [1342], 'produce': [1345], 'stiff,': [1347], 'collagen-rich': [1348], 'ECM.': [1349], 'fast': [1352], 'respond': [1353], 'increasing': [1359, 2177], 'attachment,': [1361], 'reactivating': [1363], 'MAPK': [1364], 'signaling': [1365, 1386, 2319, 2323], 'BRAF-independent': [1368], 'manner.': [1369, 3205], 'Understanding': [1370], 'cell-derived': [1373], 'regulated,': [1376], 'participates': [1380], 'remodeling': [1384], 'critical': [1388], 'developing': [1390], 'novel': [1391, 1406, 2103], 'strategies.': [1394], 'context,': [1397], 'studies': [1399], 'stromal': [1403], 'provide': [1405], 'insights': [1407], 'understanding': [1410], 'cross-talk': [1413], 'between': [1414, 1596, 1981, 3868], 'within': [1416, 2707], 'microenvironment,': [1419], 'they': [1421], 'very': [1423], 'sensitive': [1424], 'revealing': [1426], 'key': [1428], 'effectors': [1429], 'required': [1430], 'establishment': [1433], 'pre-metastatic': [1435], '(Kaplan': [1437], '2005;': [1440], 'Karagiannis': [1441], '2010;': [1444, 2664], 'Blanco': [1445], '2012).': [1448], 'therefore': [1450], 'sought': [1451], 'explore': [1453], 'analysis,': [1459, 2241, 2525, 2540, 3371, 3846], 'investigating': [1460], 'molecular': [1462, 1952, 4012], 'mechanism': [1463], 'behind': [1464], 'stiffening.': [1467], 'Results': [1468, 2282], 'vitro': [1470], 'model': [1471, 1789, 2874], 'primitive': [1475, 1492, 1511, 1536, 1582, 1618, 1673, 1700, 1726, 1792, 1804, 1972, 2007, 2305, 2345, 2373, 2400, 2437, 2484, 2766, 2825, 2925, 2947, 3025, 3242, 3413, 3721, 3814, 3838, 3886, 4008, 4069, 4081, 4106, 4133, 4190, 4227], 'With': [1477], 'aim': [1479], 'understand': [1481], 'functional': [1483], 'pathways': [1484], 'differentiate': [1486, 1980], 'phenotype,': [1493, 2343], 'investigated': [1495], 'two': [1496, 1598, 2234], 'pairs': [1497, 2744], 'matched': [1499, 1529, 1581, 1599, 2749, 3731], 'lines.': [1502, 1978, 2477, 2605, 2808, 2967, 3133, 3247, 3355, 3528, 3895], 'particular,': [1504], 'IGR39': [1505, 1620, 1638, 1727, 1747, 1759, 2251, 2401, 3825], 'IGR37': [1507, 1603, 1644, 1685, 1730, 1749, 1761, 3626, 3823, 3911, 3923], 'were': [1508, 1532, 1593, 1984, 2224, 2237, 2244, 2283, 2410, 2447, 2752, 2897, 2942, 2960, 2979, 3168, 3308, 3320, 3712, 3739, 4037, 4093, 4137], 'derived': [1509, 1533, 2052, 2838], 'node': [1515], 'metastasis,': [1516, 1540], 'respectively,': [1517, 1541, 2012], 'collected': [1518, 4078], 'same': [1521, 1544, 3141, 3296], '26-year-old': [1522], 'male': [1523], 'patient.': [1524], 'Similarly,': [1525], 'WM115': [1526, 1805, 1889, 2260, 2438], 'WM266.4': [1528, 1808, 1891], 'lines': [1531, 1556, 1565, 1712, 1829, 2063, 2308, 2522, 2561, 2751, 2769, 2819, 2837, 2851, 2949, 2987, 3039, 3045, 3071, 3119, 3144, 3167, 3214, 3299, 3307, 3319, 3585, 3733], '55-year-old': [1545], 'female': [1546], '(Fig': [1548, 1632, 1651, 2019, 2187, 2274, 2302, 2363, 2842, 2853, 2866, 2927, 3005, 3176, 3219, 3734, 3758, 4129, 4151, 4178], '1A).': [1549], 'Despite': [1550, 2291, 2904], 'common': [1552], 'origin,': [1553], 'display': [1557], 'different': [1558, 2840, 2905, 2909, 2912, 2915, 3352, 3590], 'phenotypes.': [1559], 'both': [1561, 2304, 2472, 2602, 2770, 2902, 3082, 3708, 4105], 'cases,': [1562], 'metastasis-derived': [1563, 1967, 2559], 'showed': [1566, 3751], 'faster': [1568], 'rate': [1570, 2846, 2865], 'undergo': [1575], 'division': [1577], 'tumor-derived': [1583, 1619, 1973, 2306, 2767], 'line': [1585, 1732, 1810, 3480, 3488, 3617, 3828], '(Figs': [1586, 2777], '1B': [1587], 'EV1A).': [1589], 'Differences': [1590], 'morphology': [1592], 'denoted': [1595], 'lines:': [1601], 'Metastasis-derived': [1602], 'appeared': [1604], 'short,': [1607], 'elongated': [1608], 'shape': [1609], 'spontaneous': [1612], 'predisposition': [1613], 'form': [1615, 3988], 'clusters,': [1616], 'remained': [1621], 'isolated,': [1623], 'displaying': [1624], 'branches': [1628], 'branch': [1630], 'elongations': [1631], '1C).': [1633], 'On': [1634], 'other': [1636, 2859, 3186, 3744], 'hand,': [1637], 'had': [1639], 'mobility': [1641], 'monitored': [1646], 'live': [1647], 'time-lapse': [1649, 1766], 'microscopy': [1650], '1D,': [1652], 'Movie': [1653], 'EV1': [1654, 2147, 2279], 'EV2).': [1656, 2149, 2281], 'All': [1657, 2221], 'data': [1659, 2549, 3277, 3567, 3729, 3738, 3855, 3947, 4183], 'suggest': [1660], 'isolated': [1663, 4145], 'tumors': [1666, 4070, 4082], 'grow': [1667], 'faster,': [1668], 'move': [1670, 2351], 'slower': [1671], 'than': [1672, 3719], 'tumors,': [1674, 4134], 'symptomatic': [1675], 'phenotype': [1679, 1689], '(Hoek': [1680], '2008)': [1683], 'invasive': [1688, 2342, 2811], 'IGR39.': [1691, 3913], 'Figure': [1692, 1778, 2365, 3013, 3227, 3809, 3957, 4200], '1.': [1693], 'Analysis': [1694, 1757, 1786, 2868, 3342], 'cellular': [1697, 3926], 'A.': [1704, 1800, 2378, 3030, 3274, 3829], 'Characteristics': [1705], 'IGR39/IGR37': [1707], 'WM115/WM266.4': [1709], '(Upper': [1713], 'Panel).': [1714], 'Pigmentation': [1715, 3624], 'pellets': [1719], '(lower': [1720], 'panel).': [1721], 'B.': [1722, 1821, 2388, 3043, 3341, 3860], 'Growth': [1723, 1801], 'curve': [1724, 1802], '(N': [1733, 1811], '=': [1734, 1812, 1925, 2545, 3599, 3851], '3': [1735, 1813, 2546, 3232, 3852, 3958], 'biological': [1736, 1814, 1927, 2227, 2232, 2547, 3853], 'replicates).': [1737], 'Data': [1738, 1929, 3334, 3375, 3955], 'mean': [1740, 1931, 2551, 3338, 3377, 3857], '±': [1741, 1932, 2552, 3339, 3378, 3858], 'SD.': [1742, 1933, 3340, 3379], 'C.': [1743, 1850, 2425, 3380, 3896], 'Phase-contrast': [1744], 'images': [1745, 1878, 2500, 3899, 4211], 'cells.': [1750, 1892, 3106, 3622, 3706], 'Scale': [1751, 1893, 3401, 3420, 3914, 4240], 'bar': [1752, 1894, 2511, 3402, 3421, 3915, 4241], '100': [1754], 'μm.': [1755, 1897, 2514, 3405, 3424, 3918, 4244], 'D.': [1756, 1865, 2462, 3059, 3406, 3919], 'speed': [1762], 'migration': [1764], 'microscopy.': [1767], 'Download': [1768, 1770, 1934, 1936, 2554, 2556, 3134, 3136, 3638, 3640, 3960, 3962], 'figure': [1769, 1935, 2555, 3135, 3639, 3961], 'PowerPoint': [1771, 1937, 2557, 3137, 3641, 3963], 'Click': [1772, 3007, 3221], 'here': [1773, 3008, 3222], 'expand': [1775, 3010, 3224], 'figure.': [1777, 3012, 3226, 3953], 'EV1.': [1779], '(Related': [1780, 3015, 3229], 'Figs': [1782, 3231], '1': [1783], '2)': [1785, 3018], 'Secret3D': [1796, 1859, 2106, 3034], 'Proteostat': [1798, 1880, 1918, 2502, 2535, 2754, 3218, 3366, 4096, 4213], 'analysis': [1799, 1939, 1961, 2256, 2368, 2492, 3020, 3061, 3261, 3867, 3980], 'replicates)': [1815], 'measured': [1816, 3699], 'cells/time.': [1820], 'Viability': [1822], 'profile': [1823, 3446], 'IGR': [1825, 2473, 3583], 'WM': [1827, 2262, 2475], 'after': [1830, 2030, 3635], '24-h': [1831], 'starvation,': [1832, 2065], 'measuring': [1835, 2057], 'confluence': [1837], '(%)': [1838], 'dead': [1842, 2054], 'alive': [1844, 3621], 'Muse™': [1847], 'Cell': [1848, 3044, 3150, 3267, 3281, 3580], 'Analyzer.': [1849], 'Number': [1851, 1866], 'identified': [1854, 1872, 2163, 2392, 2429], 'standard': [1863], 'protocol.': [1864, 2387], 'total': [1868, 2884, 2889, 3612, 3944], 'glycosylated': [1870, 2088, 2196], 'peptides': [1871, 2197], 'Secret3D.': [1874], 'E.': [1875, 2488, 3107, 3425, 4245], 'Confocal': [1876, 2498, 3897], 'immunofluorescence': [1877, 2524], '(1:2,000,': [1881, 2503], 'red': [1882, 2504, 3515], 'spots)': [1883, 2505], 'DAPI': [1885, 2507, 3907, 4216], 'staining': [1886, 2508, 2755, 3408, 3908, 4218], '(blue)': [1887, 3909, 4217], '10': [1896, 2513, 3351, 3917], 'F.': [1898, 2497, 3121, 3465], 'Quantitation': [1899, 2516], 'space': [1905, 2721, 2776], 'WMs.': [1907], 'Fluorescence': [1908, 3356], 'gain': [1909, 2529, 3357], 'present': [1912, 1989, 2961, 3346, 3360, 4055], 'supernatant': [1915, 3363], 'treated': [1916, 2533, 3364, 3586], 'reagent.': [1919], '(T-test,': [1920], '*P': [1921, 2541, 3328, 3576], '0.05)': [1923], 'N': [1924, 2544, 3598, 3850], '4': [1926], 'replicates.': [1928], 'Global': [1938], 'secreted': [1941, 1965, 1985, 2084, 2138, 2249, 2270, 2300, 2599, 2939, 2981, 3111, 3198], 'reveals': [1943], 'specific': [1944, 2563, 3762], 'signatures': [1945, 2485, 2813, 2926], 'To': [1949, 1979, 2731, 2784, 4061], 'investigate': [1950], 'composition': [1953], 'secretome,': [1956, 2644], 'performed': [1958, 2123, 2870, 3469], 'global': [1960], '(IGR37': [1968], 'WM266.4)': [1970], '(IGR39': [1974], 'WM115)': [1976], 'versus': [1986, 2252, 2261, 2765, 2826, 3113], 'ones': [1988], 'serum': [1992, 2034], 'cultured': [1994], 'conditions,': [1995], 'triple': [1997], 'SILAC': [1998, 2168, 2175], 'performed.': [2000, 2238], 'labeled': [2002], 'coming': [2005], 'line,': [2011], 'medium': [2014, 2028], 'heavy': [2016], 'amino': [2017], 'acids': [2018], '2A).': [2020], 'each': [2022, 2231, 2858], 'sample,': [2023], 'analyzed': [2025, 2852, 3145, 4098], 'conditioned': [2027], '(CM)': [2029], '24': [2031, 3709], 'h': [2032], 'deprivation': [2035], 'avoid': [2037], 'contamination': [2038], 'high': [2040, 2141], 'abundant': [2041, 3661, 3714], 'albumin.': [2044], 'checked': [2046], 'absence': [2049], 'viability': [2059, 3268, 3581], 'upon': [2064, 3271, 3627], 'confirmed': [2068, 3740], 'none': [2070], 'suffered': [2073], 'condition': [2075], '(viability': [2076], '95%,': [2078], 'Fig': [2079, 2153, 2205, 2590, 3017, 3995], 'EV1B).': [2080], 'As': [2081, 2150, 3654, 3992], 'far': [2082], 'highly': [2087, 2799, 2921], 'modification': [2091], 'mask': [2093], 'proteolytic': [2094], 'sites': [2095, 4087], 'hampering': [2096], 'digestion,': [2098], 'set': [2100], 'up': [2101], 'method,': [2104], 'named': [2105], '(Secretome': [2107], 'De-glycosylation': [2108, 2384], 'Double': [2109, 2385], 'Digestion': [2110, 2386], 'protocol),': [2111], 'where': [2112, 2265, 3749], 'de-glycosylation': [2114, 2186], 'step': [2115], '(PNGase)': [2116], 'added': [2118], 'prior': [2119], 'digestion': [2122, 2184], 'double': [2125], 'proteolysis': [2126], 'coverage.': [2130], 'Our': [2131], 'method': [2132], 'unambiguous': [2135], 'identification': [2136], 'efficiency': [2142], 'quantitative': [2144], 'accuracy': [2145], '(Dataset': [2146], 'reported': [2151, 3789, 3993], '2A,': [2154], 'examining': [2156], 'equivalent': [2158], '500,000': [2160], '2,356': [2164], 'IGR37/IGR39,': [2169], '2,157': [2171], 'WM266.4/WM115,': [2176], 'four': [2178], 'times': [2179], 'yield': [2181], 'without': [2185, 4167], 'EV1C,': [2188], 'Dataset': [2189, 2278], 'EV3': [2190], 'EV4,': [2192], 'Peptide': [2193, 2933], 'Atlas': [2194, 2934], 'repository;': [2195], 'represent': [2198, 2407, 2419, 2444, 2456], 'one-fourth': [2200], 'entire': [2203], 'dataset,': [2204], 'EV1D),': [2206], 'improving': [2208], 'proteome': [2210], 'coverage': [2211], 'if': [2212, 4051], 'existing': [2215], 'methods': [2216], '(Liberato': [2217], 'proteomics': [2222], 'analyses': [2223, 3468], 'done': [2225], 'duplicate,': [2228], 'replicate': [2233], 'technical': [2235], 'replicates': [2236], 'By': [2239, 3138], 'statistical': [2240], '270': [2242], 'found': [2245, 2646, 2710, 3161, 3169, 3185, 4038, 4138], 'be': [2247, 3670], 'differentially': [2248, 2269, 2299, 2938], 'IGR37.': [2253, 2404], 'A': [2254], 'parallel': [2255], 'conducted': [2258], '266.4': [2263], '185': [2273], '2B': [2275], 'C,': [2277, 3058], 'clustered': [2284], 'order': [2286, 3684], 'highlight': [2288], 'commonalities.': [2290], 'showing': [2292], 'partial': [2295], 'overlap': [2296], '2D),': [2303], 'specifically': [2309, 2803, 2980], 'secrete': [2310, 2562], 'belonging': [2312, 2565], 'degradation': [2316, 2327], '(MMP1),': [2317], 'Wnt': [2318], 'pathway': [2320, 2324, 2490], '(WNT5a),': [2321], 'TGFB': [2322], '(TPM4),': [2325], 'proteoglycan': [2326], '(SPOCK1),': [2328], 'platelet': [2330], 'activation': [2331, 3765, 3773], '(VEGFC,': [2332], 'SERPINE1,': [2333], 'EDIL3).': [2334], 'These': [2335, 3769, 4182], 'agreement': [2339], 'able': [2349], 'invade': [2353], 'basement': [2356], 'membrane': [2357], 'vessels': [2361], 'walls': [2362], '1D).': [2364], '2.': [2366], 'Proteomic': [2367, 3019], 'MS': [2379, 3031], 'workflow': [2380, 3032], 'Secret3D:': [2382], 'Secretome': [2383, 3060], 'Scatter': [2389, 2426, 3108], 'plot': [2390, 2427, 3076, 3109], 'quantified': [2394, 2431, 3079], 'Red': [2405, 2442, 3631], 'dots': [2406, 2418, 2443, 2455], 'significant': [2411, 2448, 2468, 2495, 3126, 3504], 'FDR': [2413, 2450], '0.05,': [2415, 2452, 2543, 3330], 'blue': [2417, 2454, 3099, 3527], 'P': [2422, 2459, 3495], '0.05.': [2424, 2461, 3578], 'WM266.4.': [2441], '(Left)': [2463], 'Venn': [2464, 3122], 'diagram': [2465, 3123], 'shared': [2470, 3128], '(Right)': [2478], 'Histograms': [2479], 'representing': [2480, 3862], 'H/M': [2486], 'ratios.': [2487], 'KEGG': [2489], 'enrichment': [2491, 2758], 'proteins.': [2496], 'fluorescence': [2499, 2528, 3898], '(blue),': [2509], 'scale': [2510], 'G.': [2515, 3546], 'aggregates/cell': [2518], 'IGRs': [2520, 3270], 'left': [2526], 'panel;': [2527], 'soluble': [2531], 'reagent,': [2536], 'right': [2537], 'panel.': [2538], '(T-test': [2539, 3845], 'replicates,': [2548, 3854], 'SD).': [2553, 3859], 'Conversely,': [2558, 4131], 'deposition': [2568, 2994, 3004], '(LAMA1,': [2569], 'LAMB2,': [2570], 'SPP1),': [2571], 'molecule': [2574], '(MCAM,': [2575], 'CD276,': [2576], 'EMILIN2),': [2577], 'lipid': [2578], 'transporters': [2579], '(APOE,': [2580], 'APOD,': [2581], 'PLTP,': [2582], 'VLDLR),': [2583], 'melanogenesis-related': [2585], '(DCT,': [2587], 'KIT1,': [2588], 'PMEL;': [2589], '2D': [2591], 'E).': [2593], 'Interestingly,': [2594, 4153], 'APOE': [2595, 2606, 2681, 3642, 3657, 3666, 3690, 3756, 3781, 3881], 'lipoprotein': [2609], 'whose': [2610], 'function': [2612], 'transporting': [2614], 'cholesterol,': [2615], 'controls': [2619], '(AD)': [2628], 'regulation': [2631, 3779], 'amyloid-β': [2633, 2686], '(Aβ)': [2634], 'metabolism,': [2635], 'aggregation,': [2636, 3191], 'deposition.': [2638], 'Together': [2639, 3178], 'APOE,': [2641, 2974], 'SORT1': [2648, 2978], 'QPCT,': [2650, 2976], 'known': [2652, 2697, 3668], 'role': [2656], 'facilitating': [2658], 'Aβ': [2659], 'metabolism': [2660, 3764], '(Gunn': [2661], 'Morawski': [2665], 'Notably,': [2669], 'pigmented': [2671], 'shares': [2683], 'similarities': [2684], '(Van': [2688], 'Niel': [2689], 'scaffold': [2701], 'polymerization': [2704], 'melanin': [2706, 3399], 'melanosomes.': [2708], 'all': [2711, 2848, 2945, 2963, 2983, 3130, 3448], 'above': [2713, 3146, 3509], 'included,': [2716], 'possibility': [2724], 'fibril': [2726, 3003], 'extracellularly,': [2728], 'plaques.': [2730], 'test': [2732], 'hypothesis,': [2734], 'used': [2736, 3046, 3300], 'aggregation': [2739], 'detection': [2740], 'dye': [2741], '(Proteostat).': [2742], 'Both': [2743], 'IRGs': [2746], 'WMs': [2748], 'explored:': [2753], 'highlighted': [2756], 'aggregated': [2760, 4020, 4035], 'metastasis-': [2764], 'intracellularly': [2771], '2F': [2778], 'G,': [2780], 'EV1E': [2781], 'F).': [2783], 'note,': [2785], 'fibrils,': [2787], 'adhesive': [2790, 2996], 'may': [2792], 'fibrotic': [2800], 'Proliferative': [2809], 'conserved': [2815, 2922, 2943, 3181], 'across': [2816, 3447], 'signature': [2822], 'distinguishes': [2824], 'further': [2830], 'validated': [2831], 'another': [2833], 'cohort': [2834, 3745, 3884], 'patients': [2841, 3518, 4028], 'EV2A).': [2843], 'secretion': [2845, 2917], 'EV2B)': [2854], 'differs': [2855], 'greatly': [2856], 'inversely': [2861], 'correlates': [2862], 'EV2C).': [2867], 'mixed': [2873], 'based': [2875], 'merged': [2877], 'results': [2878], 'dataset': [2880, 3437, 3570], 'normalized': [2881], 'content.': [2891], 'selected': [2893, 3290, 3559], 'statistically': [2898, 3503], 'regulated': [2900, 3671], 'approaches.': [2903], 'doubling': [2910, 3114], 'times,': [2911], 'shapes,': [2913], 'rates,': [2918], 'EV2D': [2928], 'E,': [2930], 'Datatsets': [2931], 'EV5–EV8,': [2932], 'repository).': [2935], 'Among': [2936], 'five': [2941], 'analyzed:': [2950], 'MMP1,': [2951], 'CBX5,': [2952], 'NPTXR,': [2953], 'CRIM1,': [2954], 'TPM4,': [2956], 'sixteen': [2958], 'accordance': [2969], 'our': [2971], 'previous': [2972], 'data,': [2973], 'PMEL,': [2975], 'involved': [2991, 3156, 3188], 'supporting': [2998], 'hypothesis': [3000, 4186], 'EV2F).': [3006], 'EV2.': [3014], 'applied': [3035], 'described': [3040, 3072], '(B).': [3042, 3074], 'study.': [3049], 'Their': [3050], 'origin': [3051], 'mutation': [3054], 'status': [3055], 'reported.': [3057, 3369, 3597], 'A375,': [3063, 3311], 'C32,': [3064, 3312], 'IPC298,': [3065, 3314], 'SKMEL5,': [3066, 3323], 'SKMEL28,': [3067, 3324], 'MEWO': [3068], 'Volcano': [3075], 'normalization': [3083], 'strategies': [3084], 'discussed': [3085, 3655], 'text.': [3089], 'Green': [3090], 'arrows': [3091, 3100, 3396], 'indicate': [3092, 3101, 3501], 'overexpressed': [3094, 3103], 'time': [3115, 3593], 'analyzed.': [3120], 'interrogating': [3139], 'Broad-Novartis': [3148], 'Line': [3151, 3282], 'Encyclopedia': [3152, 3283], '(CCLE),': [3153], 'transcriptomic': [3174], 'level': [3175, 3240, 3287, 3531, 3549, 3701], 'EV3A).': [3177], 'profile,': [3183], 'APP,': [3194], 'APLP2,': [3195], 'APLP1,': [3197], 'line-specific': [3204], 'Formation': [3206], 'visualized': [3216], 'EV3B).': [3220], 'EV3.': [3228], '4)': [3234], 'Gene': [3235, 3275, 3285, 3547], 'vs.': [3243], 'Mosaic': [3248, 3381], 'acquisitions': [3249], 'metastases.': [3252, 4072, 4249], 'Expression': [3253], 'profiling': [3254, 3428], 'type': [3257, 3431], 'survival': [3260, 3467, 3483, 3542], 'patients.': [3266, 3545], '(CCLE).': [3284], 'genes': [3291, 3560], 'searched': [3293], 'proteomic': [3302, 3728], 'analysis.': [3303, 3602], 'Primitive': [3304], 'WM115,': [3309], 'IGR39,': [3310], 'WM266.4,': [3321], 'IGR37,': [3322], 'MEWO.': [3326], 'T-test,': [3327], '**P': [3331, 3603], '0.001.': [3333, 3374, 3608], 'expressed': [3336, 4000], 'reagent': [3367], 'T-test': [3370, 3601], '***P': [3372, 3606, 3847], 'metastases': [3385, 4171, 4231, 4237], 'brain': [3388, 4233, 4248], 'stained': [3389, 4094], 'hematoxylin–eosin': [3391], 'Proteostat.': [3394], 'point': [3397], 'signals.': [3400], '300': [3404], 'KI-67': [3407], '(brown)': [3409], 'healthy': [3411, 4124], 'tissue,': [3412], 'indicated.': [3419, 3844], '50': [3423], 'TCGA': [3433, 3563], 'normal': [3434, 3455, 3564, 4222], 'GTEx': [3436, 3566], 'GEPIA': [3440, 3472, 3573], 'software': [3441], '(http://gepia.cancer-pku.cn/).': [3442], 'gene': [3444], 'samples': [3450, 4066, 4225], '(red': [3451], 'dots)': [3452], 'paired': [3454], 'tissues': [3456, 4142], '(green': [3457], 'dots).': [3458], 'Each': [3459], 'dot': [3460], 'represents': [3461, 3481, 3489, 3611, 3618], 'samples.': [3464], 'Overall': [3466], 'online': [3473, 3950], 'platform': [3474], 'dataset.': [3477], 'solid': [3479], 'curve,': [3484], 'dotted': [3487], 'confidence': [3492], 'interval.': [3493], 'Log-rank': [3494], '0.05': [3497], 'considered': [3499], 'difference.': [3505], 'Patients': [3506], 'median': [3511, 3523], 'indicated': [3513, 3525], 'below': [3521], '(Transcript': [3532, 3550], 'Per': [3533, 3551], 'Million,': [3534, 3552], 'TPM)': [3535, 3553], 'negatively': [3537], 'cancer/normal': [3555], 'tissue': [3556, 4128], 'extracted': [3561], 'contained': [3571], 'software.': [3574], 'T-test:': [3575], 'H.': [3579], 'NB-360': [3588, 3636], 'concentrations': [3591], 'incubation': [3595, 3628], '3,': [3600], '0.01;': [3605], 'histogram': [3610], 'number.': [3614], 'horizontal': [3616], '%': [3619], 'I.': [3623], 'NB-360.': [3630], 'box': [3632], 'shows': [3633], 'depigmentation': [3634], 'administration.': [3637], 'overrepresented': [3647], 'before,': [3656], 'secretome.': [3665], 'liverX': [3673], 'receptor': [3674, 3776], '(LXR)': [3675], 'activated': [3678], '24-': [3680], '25-hydroxycholesterol.': [3682], 'verify': [3686], 'involvement': [3688], 'cholesterol': [3693, 3763], 'metabolites': [3694], 'oxysterols': [3703], '25-hydroxycholesterol': [3711], 'thus': [3724, 3800], 'possibly': [3725], 'explaining': [3726], '3A).': [3735], 'Importantly,': [3736], '24-hydroxycholesterol': [3750], 'best': [3753], 'correlation': [3754, 3866], 'levels': [3757], '3B),': [3759], 'evidences': [3770], 'sustain': [3771], 'LXR': [3775], 'similarly': [3786], 'what': [3788], 'astrocytes': [3791], 'Abildayeva': [3793], 'coworkers': [3795], '(Abildayeva': [3796], '2006),': [3799], 'enhancing': [3801], '3.': [3810], 'Oxysterol': [3811], 'quantification': [3812], 'Absolute': [3830], 'quantitation': [3831, 3870, 3879], '24-,': [3833, 3872], '25-': [3834, 3873], '27-hydroxycholesterol': [3836, 3875], '0.001,': [3849], 'Histogram': [3861], 'R': [3863], 'square': [3864], 'absolute': [3869], 'label': [3877], 'free': [3878], '(A375,': [3887], 'IPC298)': [3888], '(SKMEL5,': [3891], 'SKMEL28)': [3892], 'anti-HMB45': [3901, 3930], 'antibody': [3903, 3932, 3983], 'signal': [3904, 4117], '(green)': [3905], 'Western': [3920, 3978], 'blot': [3921, 3979], '39': [3925], 'lysates': [3927], 'probed': [3928], 'anti': [3934], 'HDAC2': [3935], 'check': [3937], 'loading': [3939], 'amount': [3942], 'lysates.': [3945], 'available': [3949], '[embr202050446-sup-0015-SDataFig3D.pdf]': [3959], 'verified': [3966], 'presence': [3968], 'fragments': [3972], 'recognizes': [3985], 'mature': [3987, 4017], 'protein.': [3991], '3C,': [3996], 'exclusively': [3999], 'counterparts': [4009], 'weight': [4013], 'corresponds': [4014], 'form.': [4018], 'Amyloid-like': [4019], 'lesions': [4025], 'Starting': [4029], 'observation': [4032], 'particularly': [4040], 'explored': [4050], "patients'": [4059], 'tissues.': [4060], 'aim,': [4063], 'examined': [4065], 'deriving': [4067], 'Archival': [4073], 'formalin-fixed': [4074], 'paraffin-embedded': [4075], '(FFPE)': [4076], 'specimens': [4077], 'differently': [4084], 'localized': [4085, 4121], '(i.e.': [4088], 'skin,': [4089, 4223], 'brain,': [4090, 4174], 'lung)': [4092], 'high-resolution': [4100], 'large-scale': [4101], 'mosaic/confocal': [4102], 'imaging.': [4103], 'samples,': [4110], 'weak': [4114], 'absent': [4116], 'region': [4125], 'surrounding': [4126], '4A).': [4130], 'spreading': [4139], 'small': [4144], 'regions': [4146], 'inside': [4147], 'area': [4150], '4B).': [4152], 'much': [4155], 'representation': [4157], 'tissues,': [4166], 'any': [4168], 'difference': [4169], '(lung,': [4173], 'subcutaneous': [4176], 'skin)': [4177], '4C': [4179], 'D).': [4181], 'support': [4184], 'aggregation.': [4199], '4.': [4201], 'Protein': [4202], 'A–D.': [4209], 'Immunofluorescence': [4210], '(red)': [4214], '(A)': [4220], '(B)': [4224], 'melanomas,': [4228], '(C)': [4229], '(D)': [4235], 'lung.': [4239], 'Details': [4246], 'Scal': [4250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3047246294', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2024-12-20T23:45:26.766994', 'created_date': '2020-08-10'}