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[477], 'authors': [479, 686, 1353], 'showed': [480, 541, 1142], 'previously': [481], 'rats': [483], 'that': [484, 494, 542, 914, 966, 1143, 1324, 1374], 'intramyocardial': [485, 2219], 'administration': [486], 'an': [488, 1321], 'engineered': [489], 'variant': [490], 'rat': [492, 911], 'selectively': [495], 'binds': [496], '(VEGF-CC152S)': [498], 'promoted': [499], 're-establishment': [500], 'functional': [503, 1528], 'network,': [505], 'leading': [506], 'improved': [508, 579, 799, 812, 1289], 'cardiac': [509, 545, 583, 813, 826, 893, 1000, 1119, 1160, 1231, 1290, 1637, 1740, 1956, 2023, 2075], 'function.11': [510], 'present': [513, 1070], 'study,': [514], 'adeno-associated': [515], 'vectors': [517], '(AAV)': [518], 'were': [519, 662, 1094, 1354], 'systemically': [522], 'deliver': [523], 'either': [524, 766, 1109], 'human': [525, 1274, 1293], 'VEGFR-3-specific': [526], 'VEGF-CC156S,': [527, 1113], '(sVEGFR-3),': [531], 'murine': [533, 2074], 'coronary': [534], 'artery': [535], 'ligation': [536], 'models': [537], 'MI.These': [539], 'experiments': [540], 'AAV-VEGF-CC156S': [543, 578, 647, 665, 903, 1091], 'enhanced': [544, 746], '(frequency': [551], 'open': [553, 753, 807], 'lymphatics11)': [554], 'post-MI.': [555], 'This': [556, 887], 'accelerates': [557], 'resorption': [559], 'clearance': [561, 951], 'proinflammatory': [563], 'cells,': [565, 633], 'thus': [566, 855], 'limiting': [567], 'edema,': [568], 'fibrosis': [569], 'other': [571, 1134], 'destructive': [572], 'effects': [573, 957, 1089, 1128, 1954], 'chronic': [575], 'inflammation.10–12': [576], 'Concomitantly,': [577], 'multiple': [580, 713, 994, 1253, 1845], 'parameters': [581], 'measured': [585], '3': [586], 'weeks': [587], 'after': [588, 1162, 1312, 1639, 2033], 'MI,': [589, 1164], 'line': [591], 'similar': [593, 775], 'previous': [594], 'studies.11,13,14The': [595], 'most': [596], 'intriguing': [597, 1322], 'insights': [598], 'come': [599], 'dissecting': [601], 'mechanistic': [603], 'involvement': [604], 'subsets': [608, 692, 770, 1039], 'MI.': [610, 706, 1240], 'Along': [611], 'M1-polarized': [613], 'macrophages,11,12': [614], 'substantial': [616], 'T': [617, 637, 654, 657, 671, 733, 791, 820, 881, 923, 975, 1016, 1027, 1066, 1237, 1873, 1898, 1993], 'infiltrate': [619], 'was': [620, 1114], 'observed': [621, 984, 1126], 'day': [623], '3,': [624], 'comprising': [625], 'roughly': [626], 'equal': [627], 'proportions': [628], 'CD8+': [630, 769], 'CD4+': [632, 767], 'Tregs': [635, 1056], '(regulatory': [636], 'cells)': [638], 'representing': [639], 'only': [640, 674], '2%': [641], '5%': [643], 'latter.': [646], 'reduced': [648], 'accumulation': [649, 659, 673, 883, 940], 'both': [651, 666, 756, 876, 908, 915, 1055], 'macrophages': [652], 'cells.': [655], 'Interestingly,': [656, 1121], 'spatially': [663], 'linked:': [664], 'increased': [667], 'decreased': [670, 875, 1146], 'viable': [678], 'ventricle': [679, 762], 'wall,': [680], 'not': [681, 1106], 'infarct': [684, 758, 896, 1098, 1174], 'itself.The': [685], 'next': [687], 'depleted': [688], 'specific': [689, 1036], 'circulating': [690, 732], 'leukocyte': [691], 'pharmacologically': [693], 'genetically': [695], 'define': [697], 'their': [698, 857, 1234], 'impact': [699], 'endogenous': [702, 858, 969], 'Fingolimod,': [707], 'clinically': [708], 'approved': [709], 'treatment': [711, 737, 867], 'sclerosis,': [714], 'prevents': [715], 'egress': [716], 'lymphocytes': [718, 1238, 1874], 'lymphoid': [720], 'circulation': [723], 'interfering': [725], 'sphingosine-1-phosphate': [727], 'signaling.15': [729], 'Depletion': [730, 764], 'Fingolimod': [736, 811, 1310], '48': [740], 'hours': [741], 'immediately': [742, 1311], 'following': [743, 1747, 2077], 'MI': [744, 928, 1200, 1250, 1313], 'substantially': [745], 'density': [749, 802], 'frequency': [751], 'wall.': [763], 'using': [771, 1136], 'antibodies': [772], 'gave': [773], 'effect,': [776], 'suggesting': [777], 'mechanism': [779], 'common': [780], 'both.': [782], 'Antibodies': [783], 'IFN': [785], '(interferon)-γ,': [786], 'abundantly': [787], 'secreted': [788], 'effector': [790, 1065], 'inhibit': [796], 'lymphangiogenesis,16': [797], 'partially': [798], 'ameliorated': [804], 'loss': [805], 'vessels.': [809], 'Importantly,': [810], 'remodeling.': [816], 'results': [818], 'implicated': [819], 'subsequent': [831], 'MI.Some': [833], 'unexpected': [834], 'findings': [835], 'came': [836], 'animals': [838], 'treated': [839], 'AAV-VEGFR-3,': [841], 'which': [842], 'acts': [843], 'trap': [847], 'bind': [849], 'sequester': [851], 'VEGF-D,': [854], 'preventing': [856], 'through': [860, 1995], 'VEGFR-2.': [863], 'Unlike': [864], 'AAV-VEGF-CC156S,': [865], 'had': [868], 'no': [869, 1383], 'effect': [870], 'peri-infarct': [872], 'but': [874], 'infarct.': [886], 'led': [888], 'surprising': [890], 'improvements': [891], 'remodeling,': [897], 'apparently': [898], 'exceeding': [899], 'those': [900], 'seen': [901, 943], 'some': [905], 'parameters,': [906], 'mouse': [909], 'models.The': [912], 'observation': [913], 'therapeutically': [916], 'promoting': [917], 'inhibiting': [919], 'can': [921], 'reduce': [922], 'infiltration': [925, 1900], 'improve': [927, 1318], 'recovery': [929, 1147, 1251, 1319, 1638], 'at': [930], 'first': [931], 'appears': [932], 'paradoxical.': [933], 'inverse': [935], 'relationship': [936], 'lymphangiogenesis,': [942], 'also': [944, 961, 983, 1203], 'previously,11': [945], 'attributed': [947], 'accelerated': [949], 'lymphatic-mediated': [950], 'cells.12': [955], 'AAV-sVEGFR-3': [959, 1093], 'may': [960, 1267, 1339], 'involve': [962], 'nonlymphatic': [963], 'types': [965], 'respond': [967, 1784], 'VEGF-D.9': [972], 'diminished': [974], 'recruitment': [977], 'adaptive': [979], 'responses': [981], 'when': [985, 1079], 'endogenously': [989], 'artificially': [991], 'inhibited': [992], 'settings,': [996], 'cancer17': [998], 'transplantation.18': [1001], 'Insufficient': [1002], 'transport': [1004], 'antigen-presenting': [1006], 'nodes': [1011, 1046], 'impairs': [1012], 'expansion': [1013], 'antigen-specific': [1015], 'responses,': [1018], 'benefit': [1021], 'detriment': [1024], 'depending': [1025], 'type': [1029], 'pathogenesis.': [1032], 'Indeed,': [1033], 'dendritic': [1037, 1998], 'mediastinal': [1044], 'draining': [1047], 'heart': [1049], 'involved': [1051], 'generation': [1053], 'maintenance': [1058], 'peripheral': [1060, 1601], 'tolerance': [1061], 'pathogenic': [1063], 'Th1/Th17': [1064], 'MI.19The': [1069], 'study': [1071, 2234], 'further': [1072, 1326], 'highlights': [1073], 'importance': [1075], 'biological': [1077], 'context': [1078], 'developing': [1080], 'novel': [1081, 1950], 'proof-of-principle': [1082], 'therapies.': [1083], 'At': [1084], 'microenvironmental': [1086], 'level,': [1087], 'dichotomized': [1095], 'tissue.': [1102], 'Sustained': [1103], 'VEGF-CC156S': [1104], 'stimulation,': [1105], 'achieved': [1107], 'adenoviral': [1110, 1278], 'recombinant': [1112, 1263], 'required': [1115], 'maintain': [1117], 'expanded': [1118], 'lymphangiogenesis.': [1120], 'while': [1122], 'protective': [1127], 'sVEGFR-3': [1130], 'female': [1132], 'mice,': [1133], 'male': [1137], 'mice': [1138, 1154], 'mixed-sex': [1140], 'cohorts': [1141], 'blockade': [1145], 'survival': [1149, 1213], 'experimental': [1151, 1163, 1640], 'MI.14,20': [1152], 'Male': [1153], 'susceptible': [1157], 'fatal': [1159], 'rupture': [1161, 2076], 'likely': [1165], 'sex-dependent': [1168], 'differences': [1169, 1198], 'dynamics': [1172], 'scar': [1175], 'maturation.21,22': [1176], 'Responses': [1177], 'therapy': [1179], 'post-MI': [1180], 'may,': [1181], 'therefore,': [1182], 'be': [1183, 1268, 1340], 'dependent': [1184], 'sex-,': [1186], 'strain-,': [1187], 'species-specific': [1189], 'factors,': [1190], 'well': [1192], 'timing': [1194], 'treatment.9,21,22': [1196], 'Gender-related': [1197], 'pathophysiology': [1201], 'documented': [1205], 'humans,': [1207], 'although': [1208], 'reasons': [1210], 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