Title: New pathway in cancer therapy: chimeric antigen receptor-T cell therapy
Abstract: Immunotherapy has become an important way in cancer treatment. Using chimeric antigen receptor (CAR)-modified T cells in cancer treatment has become a new therapeutic approach for cancer because of its significant effect. CAR comprises an antigen-binding moiety, a hinge region, a transmembrane domain, and a cell costimulatory structure that binds to T cell leading to its activation. The specific clearance of targeted tumor is achieved by the specific selection of antigen and co-stimulatory signal transduction through CAR-T cells, the transport and maintenance of CAR-T cells after adoptive transfer, as well as retention of antitumor functions. This review addresses the current clinical and preclinical studies based on CAR-T cell therapy.
Key words:
Cancer; Chimeric antigen receptor; T cell; Immunotherapy; Clinical study
Publication Year: 2018
Publication Date: 2018-08-10
Language: en
Type: article
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