Title: Effects of simvastatin on the angiogenesis of colonic carcinoma xenograft in nude mice
Abstract: Objective To investigate the effects of simvastatin on the angiogenesis of colonic carcinoma xenografts in nude mice. Methods Twelve female athymic mice inoculated with human colonic cancer cell line colo-320 subcutaneously were randomly divided into two groups. The treatment group were administrated with simvastatin orally at a dose of 10 mg/kg. The control group were given the same volume of PBS. After 28 days tumor volume were recorded. C-fos, VEGF expression and microvascular density (MVD) of the xenograft tissue were detected by immunohistochemical staining. Results The volume of grafting tumour in treatment group (1.29±0.14)cm3 were significantly lower than those in control group (2.07±0.18)cm3 (P<0.05). C-fos,VEGF and MVD were 2.8±0.7,2.7±0.9,12.7±1.1 in carcinoma tissues treated with simvastatin, which were lower than those(5.8±1.7,4.7±1.5,20.7±1.5,respectively) in control group (P<0.05). Conclusions Simvastatin may suppress angiogenesis of colonic carcinoma xenografts in nude mice via inhibiting C-fos and reducing the expression of VEGF.
Key words:
Simvastatin ; Colonic carcinoma ; Angiogenesis ;
Publication Year: 2010
Publication Date: 2010-07-25
Language: en
Type: article
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