Title: Curcumin III inhibits growth and angiogenesis of human lung adenocarcinoma A549 xenografted in nude mice
Abstract: Objective To study the effects of bisdemethoxycurcumin (curcumin Ⅲ) on the growth and angiogenesis of human lung adenocarcinoma cell line A549 xenografted in nude mice. Methods Fifteen nude mice were inoculated subcutaneously with A549 human lung adenocarcinoma cells for two weeks. Then, the tumor bearing mice were randomly divided into 3 groups (n=5 in each group): control group,TNP-470 group, curcumin Ⅲ group. At 16 d after treatment, the nude mice were sacrificed and the tumor volume and weight were measured. The histopathological changes of the tumors were observed by HE staining. The microvessel densities (MVDs) of the tumors were measured by immunohistochemical staining with anti-CD34 monoclonal antibody. Results The mean volume and weight of the xenografted tumor in curcumin Ⅲ group was remarkably lower than those in the control group (P0.01). Moreover, MVD in curcumin Ⅲ group was also lower than that in the control group (P0.01), but was not different from that of TNP-470 group. Conclusion Curcumin Ⅲ can significantly inhibit tumor growth in nude mice bearing human lung adenocarcinoma cell line A549. The possible mechanisms may be related with the suppression of angiogenesis in tumor tissues.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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