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'abstract_inverted_index': {'目的观察不同级别人脑胶质瘤中端粒酶活性表达及与增殖、凋亡的相关性.方法采集手术中切除的不同级别人脑新鲜胶质瘤标本26例,脑外伤内减压脑组织8例,用TRAP法及TUNEL法、PCNA免疫荧光染色流式细胞仪法检测不同级别脑胶质瘤端粒酶活性以及凋亡、增殖细胞百分率.结果脑胶质瘤中端粒酶活性阳性表达率及代表端粒酶活性的平均⊿A值,在Ⅰ、Ⅱ级和Ⅲ、Ⅳ级之间差别显著(P<0.05),各个级别与对照组之间均差别显著(P<0.05).对照组脑组织端粒酶活性均为阴性.平均PCNA阳性细胞率在正常组,Ⅰ、Ⅱ级和Ⅲ、Ⅳ级之间存在显著性差异(P<0.01).TUNEL阳性细胞率在正常组与其余各组之间均存在显著差异(P<0.01),Ⅳ级与其余各组之间亦均存在显著差异(P<0.05).代表端粒酶活性的平均⊿A值(r=0.78,P<0.05)以及平均PCNA阳性细胞率(r=0.86,P<0.01)分别与胶质瘤恶性级别呈正相关.结论脑胶质瘤中,端粒酶活性阳性及PCNA阳性表达细胞率可作为预测胶质瘤化疗效果和脑胶质瘤恶性程度的标志之一,端粒酶活性表达水平和增殖活性与胶质瘤细胞恶性级别具有相关性.': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032076598', 'counts_by_year': [], 'updated_date': '2024-09-20T00:26:56.374605', 'created_date': '2020-06-05'}