Title: Serum interleukin-4 expression levels in serum of colon cancer patients and the correlation of IL-4 with embryonic antigen
Abstract: Objective To detect the serum interleukin-4 (IL-4) expression levels in colon cancer patients and observe the correlation of IL-4 expression with embryonic antigen (CEA).Methods Sixty-four colorectal cancer patients,including 46 patients with metastatic colorectal cancer (tumor burden),and 18 patients without recurrence or metastasis of cancer (without tumor burden).After taking the fasting blood,the serum level of IL-4 expression was detected using ELISA assay,and the the serum level of CEA was detected using chemiluminescent method.The correlation of IL-4 with CEA was tested using Pearson correlation coefficient.Simultaneously,the serum IL-4 change between before and after chemotherapy was compared in patients with metastatic colorectal cancer.Results The serum level of IL-4 was (116 ± 175) pg/ml in metastatic colorectal cancer patients,while (5± 15) pg/ml in control group.The serum level of IL-4 was higher in metastatic colorectal cancer patients than those in the control group,and the difference was statistically significant (P <0.01).In 64 patients,the serum levels of IL-4 and CEA were significantly correlated,and correlation coefficient γ=0.683,there was significant difference(P <0.01).In 20 metastatic patients who could be evaluated,the serum IL-4 level was decreased in 7 patients with tumor remission,while elevated in the other 13 patients without tumor remission after 2 cycles chemotherapy.Conclusions IL-4 is significantly increased in the serum of advanced colon cancer patients,and the serum level of IL-4 is significantly correlated with the serum level of CEA in colorectal cancer patients.
Key words:
Interleukin-4 ; Carcinoembryonic antigen ; Colorectal cancer
Publication Year: 2013
Publication Date: 2013-10-10
Language: en
Type: article
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