Title: Effectiveness of low-molecular weight heparin in treatment of refractory nephropathy with hypercoagulable state in children
Abstract: Objective
To evaluate the effectiveness of low-molecular weight heparin in treatment of refractory nephropathy with hypercoagulable state.
Methods
Fifteen children with refractory nephropathy who had hypercoagulable state were treated with corticosteroid and an immunosupressive agent plus low-molecular weight heparin at the dosage of 60 ~ 100A X aIU/ ( kg• d) ; they were followed-up for urine protein quantitation, serum albumin and cholesterol. Another 15 cases with similar conditions were used as control group. The control cases were treated with dipyridamole in addition to corticosteroid and the immunosupressive agent.
Results
Blood D-dimer became negative after treatment in 13 cases of the treatment group but in only 5 cases of the control group (P <0.01) . The urine protein, serum albumin and cholesterol in treatment group were (5.1 ± 3.6) g/24h, (13.6±4.3) g/L and (10.6±2.9) mmol/L, respectively, before treatment and (2.2 ± 1.6) g/24 h, (25.5 ±6.4) g/L and (8.2 ± 1.7) mmol/L after 4 weeks treatment and (0.8 ±0.8) g/24h, (32.7±3.9) g/L and (6.9 ±0.9) mmol/L, respectively, after 8 weeks treatment. These results showed that remarkable improvement was achieved in the treatment group in all the 3 parameters ( P < 0.01) .
Conclusion
These results suggest that supplement of low-molecular weight heparin in treatment of difficult-to-manage nephropathy with hypercoagulable state could reduce urine protein and serum cholesterol and increase serum albumin level. The treatment with low-molecular weight heparin was safe, effective and convenient.
Key words:
Nephrotic syndrome; Blood coagulation; Heparin, low-molecular-weight
Publication Year: 2000
Publication Date: 2000-05-16
Language: en
Type: article
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