Title: Influence of vitrification method on clinical outcome of human frozen-thawed cleaved embryo transfer
Abstract: Objective To investigate the influence of vitrification method on clinical outcome of human frozen-thawed cleaved embryo transfer.Methods In the in vitro fertilization and embryo transfer cycles,supernumerary embryos were cryopreserved by vitrification or slow-freezing sequencing method.The embryo survival rate,intact survival rate,pregnant rate and implantation rate were compared after thawing.Results In 248 vitrified embryo thaw cycles,746 vitrified embryos were thawed,and 643(86.2%) of them survived and 594(79.4%) of them intactly survived after the thawing.In 244 women,632 embryos were transferred,and 107(43.9%) of them got clinical pregnancy,the implantation rate was 26.1% (165/632).As to slow-freezing method,in 225 embryo thaw cycles,818 embryos were thawed,598 (73.1%) of them survived,436(53.3%) of them intactly survived,and 594 embryos were transferred in 225 cycles,and 74 (32.9%) of them got clinical pregnancy,the implantation rate was 15.2%(90/594).The embryo survival rate,intact survival rate,pregnant rate,implantation rate were higher in vitrification group than those in slow-freezing group (P < 0.05).Conclusion Vitrification is a more effective method of cryopreserving the human embryo than conventional slow freezing.
Key words:
Vitrification; Slow-freezing sequencing; Cleaved embryo; In vitro fertilization and embryo transfer
Publication Year: 2014
Publication Date: 2014-12-01
Language: en
Type: article
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