Title: Expression of Livin and its relationship with Caspase-3 in hepatocellular carcinoma
Abstract: Objective To explore the expression of Livin in hepatocellular carcinoma and its relationship with Caspase-3. Methods Expression of Livin and Caspase-3 were detected in hepatocellular carcinoma(n=46), para-carcinoma tissues(n=28) and normal liver tissues(n=12) by reverse transcription polymerase chain reaction (RT-PCR). Results The expression of Livin was found lowered in order in hepatocellular carcinoma, para-carcinoma tissue and normal liver tissue, which had no relationship with age, gender, the sizes of HCC, pathological types and AFP,etc (P>0.05). But it had relationship with the metastasis of HCC(P<0.05).The expression of Caspase-3 was found increased in order in those tissue. Livin expression was negatively related to Caspase-3 expression in hepatocellular carcinoma(rs=-0. 333, P<0.05).Conclusions There is high positive expression rate of Livin in HCC,which may had an important role combined with Caspase-3 in apoptosis of HCC and be a valuable diagnostic and prognostic marker of HCC.
Key words:
Hepatocellular carcinoma ; Apoptosis ; Livin ; Inhibitor of apoptosis gene ;
Publication Year: 2010
Publication Date: 2010-04-25
Language: en
Type: article
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