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'Gy/(d·f-1),连续5d,总剂量10': [3], 'Gy.于照射前、照射后4、8、13、17和21': [4], 'd分别收取标本进行检测.利用RT-PCR、免疫细胞化学检测照射前、后人鼻咽鳞癌CNE细胞MDR1及P-gp的表达;MTT法检测其耐药指数(RI)的变化,评价P-gp的功能.结果': [5], '人鼻咽鳞癌CNE细胞MDR1基因照射前呈弱表达,照后4': [6], 'd过度表达,8': [7], 'd到21': [8], 'd表达逐渐降低,与照射前比较,差异有统计学意义(P<0.05);其编码的蛋白产物P-gp照射前、照射后4和8': [9], 'd呈弱表达,13至21': [10], 'd表达增高,P-gp迟于MDR1基因高表达.MTT法检测耐药指数结果显示:照射前、照射后4和8': [11], 'd': [12, 14], 'RI值均为1,13、17和21': [13], 'RI分别增高为8、10和11.2,RI值变化的情况与P-gp的变化情况相一致.结论': [15], '人鼻咽鳞癌CNE细胞照射前MDR1及P-gp呈弱表达,有原始的低度耐药性;照射后MDR1及功能性P-gp高表达并且持续一段时间。': [16]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031174050', 'counts_by_year': [], 'updated_date': '2024-09-18T09:53:41.413035', 'created_date': '2020-06-05'}