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'https://openalex.org/W3031174050', 'https://openalex.org/W3030784684', 'https://openalex.org/W3030734271', 'https://openalex.org/W3028702440', 'https://openalex.org/W2980477502', 'https://openalex.org/W2781746121', 'https://openalex.org/W2467892002', 'https://openalex.org/W2417222362', 'https://openalex.org/W2395618894', 'https://openalex.org/W2394612500', 'https://openalex.org/W2393834375', 'https://openalex.org/W2385847674', 'https://openalex.org/W2362783191', 'https://openalex.org/W2358986475', 'https://openalex.org/W2350884215', 'https://openalex.org/W2350244677', 'https://openalex.org/W2334251157', 'https://openalex.org/W2068562307'], 'abstract_inverted_index': {'目的:探讨白血病细胞多药耐药(MDR)与细胞凋亡的关系.方法:在体外用化疗药物阿霉素(ADM)诱导白血病细胞株K562': [0], 'MDR的产生,用As2O3诱导细胞的凋亡,采用流式细胞仪检测细胞表面P糖蛋白(P-gp)的表达;荧光定量PCR检测MDR1mRNA;通过流式细胞仪检测Anexin-V判断凋亡细胞数量的多少;观察MDR与细胞凋亡的关系.结果:5': [1], 'μmol/L的ADM能诱导K562细胞MDR的产生,随着作用时间的延长,P-gp/MDR1mRNA的表达逐渐升高;P-gp/MDR1': [2], 'mRNA的表达与细胞凋亡呈负相关(r=0.68,P<0.01);在As2O3作用下,细胞凋亡增加的同时,P-gp的表达下调.结论:抗癌药物能诱导白血病细胞MDR的产生,细胞的耐药性与凋亡抑制相关,诱导细胞的凋亡能减低白血病细胞的MDR.': [3]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029296842', 'counts_by_year': [], 'updated_date': '2024-09-18T09:37:55.399500', 'created_date': '2020-06-05'}