Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3031162809', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-4497.2011.12.014', 'title': 'Changes in nitric oxide level and guanosine monophosphate activity after ischemic preconditioning in diabetes myocardium: in vivo rat hearts', 'display_name': 'Changes in nitric oxide level and guanosine monophosphate activity after ischemic preconditioning in diabetes myocardium: in vivo rat hearts', 'publication_year': 2011, 'publication_date': '2011-12-25', 'ids': {'openalex': 'https://openalex.org/W3031162809', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-4497.2011.12.014', 'mag': '3031162809'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11243420112712/494000.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2765059052', 'display_name': 'Chinese Journal of Thoracic and Cardiovaescular Surgery', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102549476', 'display_name': 'Hongguang Han', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129955', 'display_name': 'General Hospital of Shenyang Military Region', 'ror': 'https://ror.org/0340t0585', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129955']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong-guang Han', 'raw_affiliation_strings': ['Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China', 'institution_ids': ['https://openalex.org/I4210129955']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101571056', 'display_name': 'Jinsong Han', 'orcid': 'https://orcid.org/0000-0003-1832-2641'}, 'institutions': [{'id': 'https://openalex.org/I4210129955', 'display_name': 'General Hospital of Shenyang Military Region', 'ror': 'https://ror.org/0340t0585', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129955']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin-song Han', 'raw_affiliation_strings': ['Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China', 'institution_ids': ['https://openalex.org/I4210129955']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016447988', 'display_name': 'Huishan Wang', 'orcid': 'https://orcid.org/0000-0001-6523-7488'}, 'institutions': [{'id': 'https://openalex.org/I4210129955', 'display_name': 'General Hospital of Shenyang Military Region', 'ror': 'https://ror.org/0340t0585', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129955']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui-shan Wang', 'raw_affiliation_strings': ['Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China', 'institution_ids': ['https://openalex.org/I4210129955']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072537541', 'display_name': 'Nan-bin Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129955', 'display_name': 'General Hospital of Shenyang Military Region', 'ror': 'https://ror.org/0340t0585', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129955']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan-bin Zhang', 'raw_affiliation_strings': ['Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China', 'institution_ids': ['https://openalex.org/I4210129955']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080454453', 'display_name': 'Hui Jiang', 'orcid': 'https://orcid.org/0000-0002-6256-2733'}, 'institutions': [{'id': 'https://openalex.org/I4210129955', 'display_name': 'General Hospital of Shenyang Military Region', 'ror': 'https://ror.org/0340t0585', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129955']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui Jiang', 'raw_affiliation_strings': ['Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China', 'institution_ids': ['https://openalex.org/I4210129955']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100943956', 'display_name': 'Zongtao Yin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129955', 'display_name': 'General Hospital of Shenyang Military Region', 'ror': 'https://ror.org/0340t0585', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129955']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zong-tao Yin', 'raw_affiliation_strings': ['Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Surgery, The General Hospital of Shenyang Military Command, Shenyang 110016, China', 'institution_ids': ['https://openalex.org/I4210129955']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '27', 'issue': '12', 'first_page': '746', 'last_page': '748'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10378', 'display_name': 'Advanced MRI Techniques and Applications', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10372', 'display_name': 'Cardiac Imaging and Diagnostics', 'score': 0.9804, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclic-guanosine-monophosphate', 'display_name': 'Cyclic guanosine monophosphate', 'score': 0.7101996}, {'id': 'https://openalex.org/keywords/creatine-kinase', 'display_name': 'Creatine kinase', 'score': 0.6690726}, {'id': 'https://openalex.org/keywords/ischemic-preconditioning', 'display_name': 'Ischemic Preconditioning', 'score': 0.4894134}, {'id': 'https://openalex.org/keywords/creatine', 'display_name': 'Creatine', 'score': 0.46395344}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7560854}, {'id': 'https://openalex.org/C2780994212', 'wikidata': 'https://www.wikidata.org/wiki/Q422511', 'display_name': 'Cyclic guanosine monophosphate', 'level': 3, 'score': 0.7101996}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.69076306}, {'id': 'https://openalex.org/C36880943', 'wikidata': 'https://www.wikidata.org/wiki/Q409458', 'display_name': 'Creatine kinase', 'level': 2, 'score': 0.6690726}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.60099113}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.58723336}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.56673384}, {'id': 'https://openalex.org/C2779311647', 'wikidata': 'https://www.wikidata.org/wiki/Q17148404', 'display_name': 'Ischemic preconditioning', 'level': 3, 'score': 0.4894134}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.48071912}, {'id': 'https://openalex.org/C2779896295', 'wikidata': 'https://www.wikidata.org/wiki/Q223600', 'display_name': 'Creatine', 'level': 2, 'score': 0.46395344}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.43397045}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40773982}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38069353}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3399312}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.1776332}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17626396}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.13519683}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11243420112712/494000.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2765059052', 'display_name': 'Chinese Journal of Thoracic and Cardiovaescular Surgery', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3146878169', 'https://openalex.org/W3145375064', 'https://openalex.org/W3032497565', 'https://openalex.org/W3030517493', 'https://openalex.org/W3029365029', 'https://openalex.org/W3029321344', 'https://openalex.org/W2401198129', 'https://openalex.org/W2392449594', 'https://openalex.org/W2390892904', 'https://openalex.org/W2378720620', 'https://openalex.org/W2376781215', 'https://openalex.org/W2373128453', 'https://openalex.org/W2369389909', 'https://openalex.org/W2366695966', 'https://openalex.org/W2363247148', 'https://openalex.org/W2354847447', 'https://openalex.org/W2352061422', 'https://openalex.org/W2351810139', 'https://openalex.org/W2350665029', 'https://openalex.org/W2349201763'], 'abstract_inverted_index': {'Objective': [0], 'To': [1], 'study': [2], 'the': [3, 26, 129, 132, 158, 209, 212, 215, 274, 291, 294], 'changes': [4, 154, 185], 'of': [5, 16, 29, 35, 79, 82, 88, 96, 102, 121, 127, 131, 135, 155, 157, 173, 186, 188, 211, 277, 290, 293], 'nitric': [6, 11], 'oxide': [7, 12, 302], '(NO),guanosine': [8], 'monophosphate(cGMP)': [9], 'and': [10, 41, 90, 115, 144, 151, 166, 191, 201, 222, 231, 238, 257], 'synthase': [13], '(NOS)': [14], 'expression': [15, 292], 'diabetic': [17, 38, 255, 265], 'rat': [18, 283], 'heart': [19], 'after': [20], 'ischemic': [21, 278, 281], 'preconditioning': [22, 68, 279], '(IPC),and': [23], 'to': [24, 93, 118, 207], 'explore': [25], 'possible': [27], 'mechanism': [28], 'diabetes': [30], 'mellitus': [31], 'inhibiting': [32, 289], 'myocardial': [33, 189, 251], 'protection': [34], 'IPC.Methods': [36], 'Thirty': [37], 'SD': [39, 44], 'rats': [40, 45, 74, 109, 266], 'thirty': [42], 'non-diabetic': [43, 235], 'were': [46, 60, 75, 110, 138, 170, 180, 182, 193, 225, 240], 'divided': [47], 'into': [48], '3': [49], 'groups': [50], '(n': [51], '=10)': [52], 'randomly.Control': [53], 'group': [54, 69, 137, 230, 233], '(Sham': [55], 'group,n': [56, 72, 106], '=10),After': [57], 'surgery,no': [58], 'procedures': [59], 'made;': [61], 'After': [62], '155': [63], 'min,the': [64], 'experiment': [65], 'was': [66, 199, 205], 'ended.Ischemic': [67], '(': [70, 267], 'IPC': [71, 229], '=10),the': [73], 'subjected': [76, 92, 117], 'three': [77], 'cycles': [78], 'five': [80, 86], 'minutes': [81, 87, 95, 101, 114, 120, 126], 'ischemia': [83, 97, 122], 'followed': [84, 98, 123], 'by': [85, 99, 124], 'reperfusion': [89], 'then': [91, 116], '30': [94, 119], '90': [100, 125], 'reperfusion.Ischemia/reperfusion': [103], 'group(': [104], 'I/R': [105, 232], '=10),after': [107], 'surgery,the': [108], 'balanced': [111], 'for': [112], '35': [113], 'reperfusion.At': [128], 'end': [130], 'experiment,the': [133], 'hearts': [134], 'each': [136], 'excided': [139], 'quickly,frozen': [140], 'in': [141, 178, 234, 254, 264], 'liquid': [142], 'nitrogen': [143], 'stored': [145], 'at': [146], '80': [147], '℃': [148], 'until': [149], 'membrane': [150], 'cytoplasm': [152], 'preparation.The': [153], 'activities': [156], 'serum': [159], 'creatine': [160], 'kinase': [161, 163], '(CK),creatine': [162], 'isoenzyme': [164], '(CK-MB)': [165], 'lactate': [167], 'dehydrogenase': [168], '(LDH)': [169], 'detected.The': [171], 'activity': [172], 'malonyldialdehyde': [174], '(MDA),superoxide': [175], 'dismutase': [176], '(SOD)': [177], 'myocardium': [179], 'dectected': [181], 'assessed.In': [183], 'addition,the': [184], 'content': [187], 'cGMP': [190], 'NO': [192], 'assessed.Ultrathin': [194], 'sections': [195], '70': [196], 'nm': [197], 'thick': [198], 'made': [200], 'transmission': [202], 'electron': [203], 'microscopy': [204], 'used': [206], 'detect': [208], 'structure': [210], 'mitochondria': [213, 223], 'with': [214, 288], 'Flameng': [216], 'scoring': [217], 'system.Results': [218], 'Myocardial': [219], 'enzyme': [220], 'leakage': [221], 'injury': [224], 'significantly': [226, 242], 'reduced': [227], 'compared': [228], 'rats,and': [236], 'cGMP,NO': [237], 'NOS': [239, 258], 'also': [241, 260], 'increased': [243], '(P': [244], '<0.05': [245], ').There': [246], 'did': [247], 'not': [248], 'show': [249], 'significant': [250, 262], 'protective': [252, 275], 'effect': [253, 276], 'rats,cGMP.NO': [256], 'showed': [259], 'no': [261], 'increase': [263], 'P': [268], '>': [269], '0.05': [270], ').Conclusion': [271], 'Diabetes': [272], 'inhibited': [273], 'on': [280], 'reperfused': [282], 'heart,which': [284], 'may': [285], 'be': [286], 'related': [287], 'NO-cGMP': [295], 'signaling': [296], 'pathway.\r\n\r\nKey': [297], 'words:': [298], '\r\nIschemic': [299], 'preconditioning;\xa0Diabetes;\xa0Guanosine': [300], 'monophosphate;\xa0Nitric': [301]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031162809', 'counts_by_year': [], 'updated_date': '2024-12-15T08:19:00.012404', 'created_date': '2020-06-05'}