Title: Clinical efficacy of short-term intensification of gamma globulin combined with methylprednisolone sodium succinate in treatment of children with acute severe viral encephalitis
Abstract: Objective
To investigate the clinical efficacy of short-term intensive therapy with gamma globulin combined with methylprednisolone sodium succinate in the treatment of children with acute severe viral encephalitis (SVE).
Methods
A total of 82 children with SVE in Linfen People’s Hospital from January 2016 to May 2018 were randomly divided into two groups. The control group (n=41) was treated with methylprednisolone sodium succinate for 7 days, and the observation group (n=41) was added short-term intensification of gamma globulin on this basis for 2 days. The clinical efficacy and adverse reactions of the two groups were compared. The clinical symptoms and signs recoverytime and the hospital stay was measured. Serum levels of NSE were measured before and after treatment.
Results
The total effective rate of the observation group was significantly higher than that of the control group (97.56% vs. 85.37%, P 0.05).
Conclusions
Short-term intensive therapy with gamma globulin combined with methylprednisolone sodium succinate is safe and effective in treatment of children with SVE, which can repair nerve damage and promote disease recovery.
Key words:
Severe viral encephalitis; Children; Gamma globulin; Methylprednisolone sodium succinate
Publication Year: 2019
Publication Date: 2019-12-25
Language: en
Type: article
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