Title: The study on gene expression of p53 、p63、p73 in colorectal tumours and the relations with cancerous and prognosis
Abstract: Objective This study was undertaken to investigate the expression of p53、p63and p73 gene in colorectal cancers, and analysis correlation of p53、p63and p73 with originating and prognosis of colorectal tumors. Methods Using a polymerase chain reaction (PCR)approach, we analysed the expression in exon5 of p53, exon6 of p63, exon2 of p73 in 58 human colorectal cancer and 50 colorectal polypi patients. Results 43 of 58colorectal tumour patients expressed P53 gene group,37 of 50 colorectal polypi patients expressed P53 gene group.Conclusion There was affinity between P53 gene group and the colorectal tumour patients' prognosis.
Key words:
p53; p63; p73; Colorectal tumor; Gene; Suppress gene; PCR
Publication Year: 2010
Publication Date: 2010-02-25
Language: en
Type: article
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