Title: Changes of urinary trace protein levels in patients with systemic lupus erythematosus
Abstract: Objective To study the changes of urinary trace protein levels in patients with systemic lupus erythematosus(SLE) and its clinical significance.Methods The levels of urinary α 1-microglobulin (α 1-MG),β 2-microglohulin(β 2-MG),transferrin(TRF),microalbumin(MA),and immunoglobulin G(IgG)were detected by immunturbidimetry,N-acetyl-β-D-glucoseaminidase enzyme(NAG) was detected by biochemistry,and serum creatinine (Cr) was detected in 52 patients with SLE(SLE group) and 40 healthy volunteers(control group).The data was analyzed by IBM SPSS Statistics.Results The levels of ot 1-MG,NAG,β 2-MG,TRF,MA,and IgG were significantly higher in the SLE group than in the control group (P < 0.01).The positive rate of combined detection of urinary trace proteins was higher than that of serum Cr (P < 0.01).There was a statistical difference between the positive rate of combined detection of o 1-MG,NAG,and β 2-MG and the positive rate of combined detection of TRF,MA,and IgG in patients with SLE(P < 0.05).The positive rates of IgG and TRF were higher than that of MA(P < 0.05,P < 0.05).The positive rates of β 2-MG and o 1-MG were higher than that of NAG(P < 0.01,P < 0.01).Conclusions Urinary o 1-MG,NAG,β 2-MG,TRF,MA,and IgG levels increase in patients with SLE and can be applied on early diagnosing the renal function injury of the patients with SLE.The patients with SLE are more likely to have renal tunnel function injury than to have renal glomerular function injury.Urinary IgG and urinary TRF are more sensitive than urinary MA in indicating the injury of renal glomerular function in patients with SLE.Urinary β 2-MG and urinary o 1-MG are more sensitive than urinary NAG in indicating the injury of renal tunnel function in patients with SLE.
Key words:
Systemic lupus erythematosus; α1-microglobulin; N-acetyl-β-D-glucosamini dase enzyme; β2-microglobulin; Transferrin; Microalbumin; Immunoglobulin G
Publication Year: 2013
Publication Date: 2013-11-01
Language: en
Type: article
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