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'https://openalex.org/W3029290478', 'https://openalex.org/W3029034887', 'https://openalex.org/W3028864598', 'https://openalex.org/W3028680804', 'https://openalex.org/W2390071866', 'https://openalex.org/W2385431610', 'https://openalex.org/W2373051246', 'https://openalex.org/W2348798844', 'https://openalex.org/W2030211638', 'https://openalex.org/W1174791373'], 'abstract_inverted_index': {'目的': [0], '检测鸡眼巩膜纤维层MMP-2和TIMP-2的表达,进一步阐明近视鸡眼巩膜重塑的机制.方法采用形觉剥夺的方法建立鸡眼近视模型.提取鸡眼巩膜纤维层的总RNA和蛋白质.利用RT-PCR和Western': [1], 'blot技术检测MMP-2和TIMP-2的mRNA和蛋白质表达水平的改变.结果近视组鸡眼巩膜纤维层MMP-2': [2], 'mRNA和蛋白质表达水平明显升高,分别是正常组的2.14和2.11倍,差异显著(P<0.01,P<0.01),而TIMP-2的表达水平较正常组分别下降55.05%和53.73%,差异亦显著(P<0.01,P<0.05).结论近视鸡眼巩膜纤维层变薄是组织主动重塑的结果,至少部分是由于MMP-2和TIMP-2表达改变所致。': [3]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030679656', 'counts_by_year': [], 'updated_date': '2024-09-18T09:50:48.345623', 'created_date': '2020-06-05'}