Title: Short-term follow-up study and pregnancy rate of polycystic ovary syndrome patients treated with letrozol combined with human menopause gonadotropin
Abstract: Objective
To investigate the short-term efficacy and pregnancy rate of letrozol combined with human menopause gonadotropin in the treatment of infertile patients with polycystic ovary syndrome.
Methods
A total of 64 cases of PCOS infertility in hospital from June 2014 to April 2017 were selected, according to the random number table method, they were divided into observation group and control group, 32 cases in each group. On the basis of routine treatment, control group was given the menopause gonadotropin, and observation group was added to letrozol on the basis of control group trazole. All groups were treated for 3 menstrual cycles. The level of serum sex hormones (luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T) before and after treatment, ovarian volume, and the thickness of endometrium at the fifth day of the next menstrual cycle after treatment and during the perinatal period of ovulation were compared between the two groups. The ovulation rate, pregnancy rate (follow up for 6 months after the end of treatment) and the incidence of adverse reactions during the treatment of two groups were also statistically analyzed.
Results
① Sex hormone levels: there was no statistically significant difference in serum LH, T and FSH levels between the two groups before treatment (P>0.05). There were insignificant change in serum level of FSH after treatment in the two groups compared with that before treatment(P>0.05). The serum LH and T decreased after treatment compared with that before treatment(P 0.05). After treatment, the ovarian volume of the two groups decreased compared with that before treatment (P 0.05). There was no statistically significant difference in endometrial thickness between the two groups on the 5th day of menstruation (P>0.05). The periovulatory endometrial thickness in the observation group was greater than that in the control group (P 0.05).
Conclusions
Combination of menopausal gonadotropin and letrozole in the treatment of PCOS infertility can improve serum sex hormone levels, reduce ovarian volume and increase endometrial thickness in the period of ovulation, which is helpful for improving pregnancy rate and Have a certain safety.
Key words:
Polycystic ovarian syndrome; Infertility; Human menopause gonadotropin; Letrozole; Pregnancy rate
Publication Year: 2018
Publication Date: 2018-08-25
Language: en
Type: article
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