Title: Study on the preventive effect of hepatitis B immunoglobulin for the hepatitis B virus vertical transmission
Abstract: Objective To observe the preventive effect of hepatitis B immunoglobulin (HBIG) for the HBV mother-infant vertical transmission.Method 200 HBsAg( + ) pregnant women were divided into three groups according to their will.Pregnant women in group A (n=75) were given HBIG since pregnancy 28 weeks and within 24 hours after parturition, besides their newborns. Pregnant women in group B (n = 85) were injected HBIG within 24 hours after partu-rition. Pregnant women in group C (n = 40) didn't take HBIG. Newborns in three groups were all taken HBV vaccine. Mather-infant vertical transmission standards: HBV DNA was positive either within 24 hours or six months after parturi-tion.Results The positive rates of HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc had no statistical difference in pregnancy 28 weeks mothers' serum( P > 0.05). After injected HBIG three times, group A had different positive rates of HBsAg, HBeAg and anti-HBs, compared with those in other two groups( P < 0.05, P < 0.01 ). The HBV DNA positive rates in milk had statistical difference between three groups( P < 0.05, P < 0.01) .The HBV infection rates of newborns and six month infants were group A < B < C( P < 0.05, P < 0.01). Conclusions HBIG intramuscular injection has obvi-ously preventive effect for the HBV mother-infant vertical transmission, and may decrease the risk of infection by maternal breast-fed.
Key words:
Immunoglobulin; Vertical transmission; Hepatitis B virus
Publication Year: 2008
Publication Date: 2008-12-25
Language: en
Type: article
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