Title: Effect of the timing for intraoperative tramadol on postoperative analgesia
Abstract: Objective To compare the anesthesic depth,postoperative analgesia and side-effects between patients who received double doses of intraoperative tramadol when on induction and near the end of the operation,and those who received single dose of tramadol only near the end of the operation.Methods Sixty patients undergoing laparotomy were involved in this study and randomly divided into 2 groups by using a computer-generated random number table.The patiens in group A received 1.5 mg/kg tramadol for twice when on induction and 30 min before the end of the operation.And the patiens in group B received a single dose of 1.5 mg/kg tramadol 30 min before the end of the operation.bispectral index(BIS)was recorded before and after tramadol administration.The recovery from anesthesia,visual analogue scale(VAS)and side-effects of postoperative analgesia were monitored.Results There was no difference in the baseline characteristics between two groups.BIS were comparable before and after tramadol administration in both groups(P>0.05).VAS was significantly lower in group A than in group B at the time of postoperative 0.5,2,6 h and 12 h,respectively(VAS 3.4±0.5,3.2±0.5,3.1±0.4 and 3.1±0.4 in group A vs 3.9±0.6,3.6±0.6,3.4±0.6 and 3.4±0.5 in group B correspondingly,P<0.05 or P<0.01),while there was no difference at the time of postoperative 24 h or 48 h.Ramsay scores,incidence of postopertive nausea and vomiting(PONV),dizziness,and supplemental analgesics did not show different between groups.Conclusions The double-dose protocol of intraoperative tramadol administered when on induction and near the end of the operation showed better postoperative analgesia without increasing the side-effects in the first postoperative 12 h.
Key words:
Tramadol; Analgesia, patient-controlled; Analgesics
Publication Year: 2012
Publication Date: 2012-01-15
Language: en
Type: article
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