Title: Effect of gabapentin on tramadol postoperative analgesia after gastric cancer operations
Abstract: Objective To investigate the effect of gabapentin on postoperative analgesia with tramadol in patients after gastric cancer operations.Methods Forty patients(ASA Class Ⅰ or Ⅱ)underwent gastric cancer operations were randomly allocated to either test group or control group with 20 cases each.The patients in test group were given gabapentin 1 200 mg at 2.5 h before the surgery.In control group,oral placebo was given instead of gabapentin.All patients received PCA with tramadol with a 50 mg initial loading dose,20 mg incremental dose,10 min lockout interval,and 1 h limit of 120 mg.The incremental dose of 30 mg was alternated if analgesia was inadequate 1 h later.VAS scores,heart rate(HR),mean blood pressure(MAP),respiratory rate(RR)and total use of tramadol were recorded at 1,4,8,12,16,20,24 h after surgery.Results The VAS scores were significantly lower in test group than those in control group(P0.05).The total dosage of tramadol of test group was(317.5±69.6)mg,which was significantly less than that of the control(576.5±106.2)mg(P0.01).There were no significant differences in HR,MAP,RR and adverse effects between two groups.Conclusion Preemptive use of gabapentin can enhance postoperative analgesia with tramadol in patients after gastric cancer operations.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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