Publication Information

{'id': 'https://openalex.org/W3030134733', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-5101.2019.05.002', 'title': 'Preliminary study on the effects of costimulatory molecule B7-H3 on the invasion and survival of human non-small cell lung cancer cell line A549', 'display_name': 'Preliminary study on the effects of costimulatory molecule B7-H3 on the invasion and survival of human non-small cell lung cancer cell line A549', 'publication_year': 2019, 'publication_date': '2019-05-31', 'ids': {'openalex': 'https://openalex.org/W3030134733', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-5101.2019.05.002', 'mag': '3030134733'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN112309201905/1149236.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2756093131', 'display_name': 'Zhonghua weishengwuxue he mianyixue zazhi', 'issn_l': '0254-5101', 'issn': ['0254-5101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 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'https://openalex.org/W2075748654'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 9, 27, 77, 95, 173, 183, 191, 243, 249], 'effects': [3], 'of': [4, 13, 29, 99, 106, 151, 175, 194, 213, 220, 251], 'costimulatory': [5], 'molecule': [6, 253], 'B7-H3': [7, 30, 114, 146, 252], 'on': [8, 34, 118], 'proliferation': [10, 59, 139, 260], 'and': [11, 55, 62, 81, 97, 101, 126, 208, 215, 217, 223, 261, 270], 'invasion': [12, 98], 'human': [14], 'non-small': [15], 'cell': [16, 19, 82, 124, 129, 138, 157, 166, 195, 259, 264, 272], 'lung': [17], 'cancer': [18], 'line': [20, 125, 130], 'A549.\r\n\r\n\r\nMethods\r\nFlow': [21], 'cytometry': [22, 72], 'was': [23, 39, 73, 91, 109, 115, 140, 159, 180, 246], 'used': [24, 92], 'to': [25, 45, 75, 93], 'detect': [26, 76], 'expression': [28, 212, 219, 250], 'at': [31, 190, 267], 'protein': [32], 'level': [33], 'A549': [35, 42, 64, 103, 119, 132, 137, 165, 201, 236, 255], 'cells.': [36, 104, 120], 'B7-H3-targeting': [37], 'siRNA': [38], 'transfected': [40], 'into': [41], 'by': [43, 68, 111], 'lentivirus': [44], 'construct': [46], 'B7-H3-A549': [47, 61, 100, 123, 156, 186, 203, 228], 'cells,': [48, 202, 237], 'which': [49], 'were': [50, 66, 133, 188, 225], 'identified': [51], 'with': [52, 199, 232], 'Western': [53, 112], 'blot': [54], 'qPCR.': [56], 'Differences': [57], 'in': [58, 79, 155, 163, 172, 227, 234, 242, 254], 'between': [60, 182], 'B7-H3+': [63, 102, 131, 164, 200, 235], 'cells': [65, 154, 176, 187, 204, 229, 256], 'analyzed': [67], 'CCK8': [69], 'assay.': [70], 'Flow': [71], 'performed': [74], 'changes': [78], 'apoptosis': [80, 179], 'cycle': [83, 265], 'after': [84, 143], 'AnnexinⅤ-PE/propidium': [85], 'iodide': [86], '(PI)': [87], 'staining.': [88], 'Transwell': [89], 'assay': [90], 'evaluate': [94], 'migration': [96, 207], 'Expression': [105], 'apoptosis-related': [107], 'proteins': [108], 'detected': [110, 226], 'blot.\r\n\r\n\r\nResults\r\n(1)': [113], 'highly': [116], 'expressed': [117], 'A': [121], 'stable': [122], 'its': [127], 'control': [128], 'successfully': [134], 'prepared.': [135], '(2)': [136], 'significantly': [141], 'reduced': [142], 'knocking': [144], 'down': [145, 248], 'expression.': [147], '(3)': [148], 'The': [149], 'percentage': [150], 'early': [152], 'apoptotic': [153], 'group': [158], 'higher': [160], 'than': [161], 'that': [162], 'group,': [167], 'but': [168, 238], 'no': [169, 239], 'significant': [170, 240], 'difference': [171, 241], 'percentages': [174], 'undergoing': [177], 'late': [178], 'found': [181], 'two': [184], 'groups.': [185], 'arrested': [189], 'G0/G1': [192, 268], 'phase': [193, 269], 'cycle.': [196], '(4)': [197], 'Compared': [198], 'showed': [205], 'suppressed': [206], 'invasion.': [209], '(5)': [210], 'Enhanced': [211], 'Bad': [214], 'Caspase-3': [216], 'decreased': [218], 'Bcl-2,': [221], 'P-AKT': [222], 'MMP-9': [224], 'as': [230], 'compared': [231], 'those': [233], 'total': [244], 'AKT': [245], 'observed.\r\n\r\n\r\nConclusions\r\nKnocking': [247], 'could': [257], 'inhibit': [258], 'invasion,': [262], 'induce': [263], 'arrest': [266], 'promote': [271], 'apoptosis.\r\n\r\n\r\nKey': [273], 'words:': [274], '\r\nA549': [275], 'cell;\xa0B7-H3;\xa0Invasion;\xa0Apoptosis': [276]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030134733', 'counts_by_year': [], 'updated_date': '2024-12-15T21:03:52.086640', 'created_date': '2020-06-05'}