Publication Information

{'id': 'https://openalex.org/W3029991002', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-9030.2019.11.034', 'title': 'Osthole inhibits pancreatic cancer cell cycle progression and proliferation by inducing reactive oxygen species', 'display_name': 'Osthole inhibits pancreatic cancer cell cycle progression and proliferation by inducing reactive oxygen species', 'publication_year': 2019, 'publication_date': '2019-11-08', 'ids': {'openalex': 'https://openalex.org/W3029991002', 'doi': 'https://doi.org/10.3760/cma.j.issn.1001-9030.2019.11.034', 'mag': '3029991002'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://rs.yiigle.com/CN421213201911/1168453.htm', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 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[{'raw_affiliation_string': 'Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101792241', 'display_name': 'Fang Zhou', 'orcid': 'https://orcid.org/0000-0001-9581-9331'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Zhou', 'raw_affiliation_strings': ['Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101621355', 'display_name': 'Jian Yang', 'orcid': 'https://orcid.org/0000-0001-5772-151X'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Yang', 'raw_affiliation_strings': ['Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101671533', 'display_name': 'Dechun Li', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dechun Li', 'raw_affiliation_strings': ['Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046440756', 'display_name': 'Jian Zhou', 'orcid': 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'https://openalex.org/W3030478804', 'https://openalex.org/W3029662562', 'https://openalex.org/W2589816016', 'https://openalex.org/W2409859114', 'https://openalex.org/W2398083189', 'https://openalex.org/W2392914652', 'https://openalex.org/W2388106711', 'https://openalex.org/W2388077611', 'https://openalex.org/W2385834720', 'https://openalex.org/W2362495295', 'https://openalex.org/W2360754952', 'https://openalex.org/W2359058405', 'https://openalex.org/W2353733061', 'https://openalex.org/W2245964727'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 20, 37, 104, 109, 220, 228, 261, 274], 'oxidative': [3], 'stress': [4], 'damage': [5], 'and': [6, 14, 36, 64, 79, 108, 142, 227, 246, 302], 'mechanism': [7], 'of': [8, 22, 34, 39, 74, 95, 99, 106, 114, 187, 219, 237, 277], 'osthole': [9], '(Ost)': [10], 'on': [11], 'panc-1': [12, 82, 100, 296], 'cells,': [13], 'to': [15, 258], 'provide': [16], 'experimental': [17], 'evidence': [18], 'for': [19], 'treatment': [21], 'pancreatic': [23], 'cancer': [24], 'with': [25, 31, 139], 'Chinese': [26], 'medicine.\r\n\r\n\r\nMethods\r\nPanc-1': [27], 'cells': [28, 40, 83, 101, 297], 'were': [29, 67, 123, 255, 288], 'treated': [30], 'different': [32], 'concentrations': [33], 'Ost,': [35, 107], 'proliferation': [38, 97, 304], 'was': [41, 50, 84, 153, 211, 225, 231], 'detected': [42, 51, 68, 85], 'by': [43, 52, 69, 86, 147, 214, 305], 'Alamar': [44], 'blue': [45, 54, 165], 'method.': [46, 56], 'The': [47, 57, 72, 89, 150, 216, 233], 'cell': [48, 65, 171, 307], 'viability': [49], 'trypan': [53], 'counting': [55], 'cellular': [58], 'reactive': [59], 'oxygen': [60], 'species': [61], '(ROS)': [62], 'content': [63], 'cycle': [66], 'flow': [70], 'cytometry.': [71], 'expression': [73, 235, 276], 'Cyclin': [75, 77, 238, 247], 'D1,': [76], 'D3': [78, 248], 'Notch1': [80, 278], 'in': [81, 170, 295, 298], 'Western': [87, 266], 'blotting.': [88], 'statistical': [90], 'method': [91], 'used': [92], 'one-way': [93], 'analysis': [94], 'variance.\r\n\r\n\r\nResults\r\nThe': [96], 'activity': [98], 'decreased': [102], 'under': [103], 'action': [105], 'concentration-dependent,': [110], 'drug': [111], 'inhibition': [112], 'rates': [113], '10,': [115], '20,': [116], '40,': [117], '80,': [118], '120,': [119], '160,': [120], '200': [121], 'μmol/L': [122, 223], '(0.095±0.056)%,': [124], '(0.164±0.033)%': [125], '(0.201±': [126], '0.034)%,': [127], '(0.267±0.037)%,': [128], '(0.537±0.028)%,': [129], '(0.732±0.015)%,': [130], '(0.936±0.002)%.': [131], 'Flow': [132], 'cytometry': [133], 'results': [134, 287], 'showed': [135, 167, 269], 'that': [136, 270], 'ROS': [137, 151, 294], 'increased': [138], 'increasing': [140], 'concentration': [141], 'could': [143], 'be': [144], 'effectively': [145], 'reversed': [146], 'antioxidant': [148], '(NAC).': [149], 'value': [152], '0': [154, 173, 193, 202], 'μmol/L:': [155, 158, 162, 174, 177, 182, 194, 197, 203, 206, 241, 244, 250, 253, 281, 284], '17.700±0.795,': [156], '80': [157, 161, 176, 181, 243, 252, 283], '19.750±0.101,': [159], 'NAC+': [160, 221], '17.850±0.236.': [163], 'Trypan': [164], 'count': [166], 'a': [168, 299], 'decrease': [169, 259], 'viability,': [172], '100.000±7.536,': [175], '65.610±4.351,': [178], 'NAC': [179], '+': [180], '76.110±1.603.': [183], 'After': [184], '48': [185], 'h': [186], 'Ost': [188, 271], 'effect,': [189], 'G0/G1': [190, 217], 'phase': [191, 200, 218, 230], 'increased,': [192], '(57.920±2.091)%,': [195], '120': [196, 205, 222], '(70.090±1.558)%;': [198], 'G2/M': [199, 229], 'decreased,': [201], '(26.080±1.674)%,': [204], '(16.730±': [207], '0.781)%.': [208], 'This': [209], 'effect': [210], 'also': [212, 256, 268], 'inhibited': [213], 'NAC.': [215], 'group': [224], '(64.700±2.191)%,': [226], '(22.390±1.657)%.': [232], 'relative': [234, 275], 'levels': [236], 'D1': [239], '(40': [240, 249, 280], '0.804±0.067,': [242], '0.462±0.118)': [245], '0.845±0.035,': [251], '0.372±0.096)': [254], 'shown': [257], 'at': [260], 'protein': [262, 279], 'level.': [263], 'In': [264], 'addition,': [265], 'blotting': [267], 'can': [272, 292], 'down-regulate': [273], '0.949±0.027;': [282], '0.586±0.043).': [285], 'All': [286], 'statistically': [289], 'significant': [290], '(P<0.05).\r\n\r\n\r\nConclusion\r\nOst': [291], 'increase': [293], 'concentration-dependent': [300], 'manner': [301], 'inhibit': [303], 'blocking': [306], 'cycle.\r\n\r\n\r\nKey': [308], 'words:': [309], '\r\nOsthole;\xa0Pancreatic': [310], 'cancer;\xa0Oxidative': [311], 'stress;\xa0Proliferation': [312]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029991002', 'counts_by_year': [], 'updated_date': '2024-12-24T07:13:07.138967', 'created_date': '2020-06-05'}