Title: Different expression of integrinα5β3 and CD44v6 in follicular thyroid carcinoma and follicular thyroid adenoma
Abstract: Objective To study the different expression of integrinα5β3 and CD44v6 in follicular thyroid carcinoma and follicular thyroid adenoma and their clinical value. Methods Immnnohistochemical methods was used to examine expression of integrinα5β3 and CD44v6 in 60 follicular thyroid carcinoma patients,60 follicular thyroid adenoma and 60 normal thyroid tissues.Results The positive expression of integrinα5β3 in group A was 56.67% ,while in group B was 11.67%. The positive expres-sion of CD44v6 in group A was 58.33% ,while it was 10.00% in group B. These results indicated differenee between A group and B group (P <0.05). Integrinα5β3 and CD44v6 were negative in group C. Conclusion Integfinα5β3 and CD44v6 protein are useful in early diagnosis of follicular thyroid carcinoma.
Key words:
Follicular thyroid carcinoma; Follicular thyroid adenoma; lmmunohistochemistry; Integrinα5β3; CD44v6
Publication Year: 2008
Publication Date: 2008-08-25
Language: en
Type: article
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