Title: Immunohistochemical study of gonadotropin-releasing hormone receptor in human thyroid tumor
Abstract: AIM To study presence of gonadotropin releasing hormone receptor (GnRH R) in human thyroid tumor and its cellular location. METHODS Immunohistochemical ABC method and image analysis were used to study the expression and location of Gn RH R in human thyroid adenoma and carcinoma. RESULTS Partial cells of thyroid adenoma and carcinoma showed immunoreactivity. The reactive substances were distributed in cytoplasm of all positive cells with immuno negative nuclei. The staining intensity in thyroid adenoma was stronger than that in thyroid carcinoma. And normal thyroid follicular epithelia cells adjacent to tumor and normal thyroid follicular epithelia cells showed GnRH R immunoreactivity too. The cytoplasm was dark brown while the nuclei showed no staining. Image analysis suggested that relative quantification of GnRH R was 0.074±0.013, in thyroid adenoma and 0.033±0.011 in thyroid carcinoma, which suggested a significant difference ( P 0.05). And the relative amount in normal thyroid follicular epithelia cells adjacent to tumor and normal thyroid follicular epithelia cells was 0.018±0.007, which was lower than that in tumor group ( P 0.05). CONCLUSION There is GnRH R in thyroid tumor indeed. GnRH R may correlate to differentiation degree of thyroid tumor. It suggests that GnRH may take part in the regulation of developing thyroid tumor.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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