Title: Relationship Between Onset Gestational Age and Materal and Perinatal Prognosis in Severe Preeclampsia
Abstract: Objective
To analyze the effects of severe preeclampsia at different gestational ages on the maternal and perinatal outcomes.
Methods
From January 2007 to October 2013, the clinical data of 468 severe preeclampsia patients were analyzed retrospectively in the study. According to their gestational weeks, they were divided into group A (n=75, gestational week<28 weeks), group B (n= 99, 28 weeks≤gestational week<31+6 weeks), group C (n = 84, 32 weeks≤gestational week<34 weeks) and group D (n=210, gestational week≥34 weeks). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First Affiliated Hospital of Guangxi Medical University. Informed consent was obtained from each participants. The maternal and perinatal outcomes among four groups were compared.
Results
There were no significant differences in age, systolic blood pressure, diastolic blood pressure among four groups (F=0.936 4,0.129 7,0.722 8; P = 0.422 9,0.942 4,0.538 8) and no significant differences were found in incidence rates of complications among four groups (χ2 = 7.312 0, 1.347 3,0.465 5,2.486 3,2.576 6,2.077 1,4.387 4,2.261 0,20.657 0;P>0.05). The differences of gestational age at onset, gestational age at delivery and expectant treatment duration among four groups had statistically significant (F=396.356 6,238.161 1,207.104 6;P = 0.000). Perinatal mortality, the incidence rates of neonatal asphyxia and neonatal respiratory distress syndrome (NRDS) in group A and group B were significantly higher than those of group C and group D (P 0.05).
Conclusions
The gestational age of the onset of severe preeclampsia and expectant treatment duration were unrelated to the maternal outcomes. Gestational week at 32 weeks may be the best critical value of diagnosis of early onset severe preeclampsia(EOSP).
Key words:
Pre-eclampsia; Gestational age; Pregnancy outcome
Publication Year: 2014
Publication Date: 2014-08-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot