Title: Protective effect of L-arginine on lung preservation
Abstract: Objective: This study was to investigate the protective effect of L-arginine infusion on lung preservation in a isolated-lung reperfusion model. Methods: 14 New Zealand white rabbits were randomly divided into two groups. In the control group, the lungs were flushed and preserved with modified Euro-Collins solution(ECS) while in the treated group, 3?mmol/L L-Argninine were added to Euro-ccollins solution. The harvested blocks were preserved at 4℃ for 6 hours and reperfused with whole blood for pulmonary functional assessment. The protective effects was assessed by measuring partial oxygen tension of pulmonary venous effluent blood, the content of nitric oxide(NO), superoxide dismutase (SOD) and lipid peroxide (LPO) in the blood and the lung tissues, and the ultrastructural studies of lung. Results: The PpvO2 at 5 min after reperfusion was significantly higher in the treated group than in the control group. The concentration of NO and SOD in the pulmonary venous blood and the lung tissue was significanlty higher in the treated group than in the control group, however, the change of LPO was adverse. Transmission electron microscopic examination showed the lesions in the treated group was milder than in the control group. Conclusion: The protective effects of L-Arginine in conjunction with modified ECS flush and storage were surperior. It can attenuate the lung injury by cold preservation, ischemia, and ischemia-reperfusion during the 6 hours lung preservation.
Publication Year: 2001
Publication Date: 2001-05-25
Language: en
Type: article
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