Publication Information

{'id': 'https://openalex.org/W3029653290', 'doi': 'https://doi.org/10.3760/cma.j.issn.1004-4221.2018.01.022', 'title': 'PDTC attenuates radiation-induced heart damage by inhibiting the activation of NF-κB and its downstream signaling pathways in rats', 'display_name': 'PDTC attenuates radiation-induced heart damage by inhibiting the activation of NF-κB and its downstream signaling pathways in rats', 'publication_year': 2018, 'publication_date': '2018-01-15', 'ids': {'openalex': 'https://openalex.org/W3029653290', 'doi': 'https://doi.org/10.3760/cma.j.issn.1004-4221.2018.01.022', 'mag': '3029653290'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN113030201801/1018235.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764439201', 'display_name': 'Zhonghua fangshe zhongliuxue zazhi', 'issn_l': '1004-4221', 'issn': ['1004-4221'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 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'raw_author_name': 'Lina Liu', 'raw_affiliation_strings': ['Department of Radiotherapy Oncology, The 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiotherapy Oncology, The 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China', 'institution_ids': ['https://openalex.org/I111381250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102333200', 'display_name': 'Yajing Wu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yajing Wu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046960896', 'display_name': 'Guangbin Gao', 'orcid': 'https://orcid.org/0009-0009-3460-8712'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Guangbin Gao', 'raw_affiliation_strings': [], 'affiliations': []}, 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'https://openalex.org/W3025142517', 'https://openalex.org/W3024681784', 'https://openalex.org/W3023543213', 'https://openalex.org/W3021756569', 'https://openalex.org/W2413234191', 'https://openalex.org/W2398665448', 'https://openalex.org/W2393275571', 'https://openalex.org/W2382807046', 'https://openalex.org/W2372693733', 'https://openalex.org/W2366826445', 'https://openalex.org/W2360450033', 'https://openalex.org/W2310890353', 'https://openalex.org/W2169210409'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'whether': [2], 'pyrrolidine': [3], 'dithiocarbamate': [4], '(PDTC)': [5], 'can': [6, 259], 'attenuate': [7], 'the': [8, 16, 37, 51, 57, 71, 100, 117, 171, 174, 181, 189, 196, 209, 215, 222, 226, 238, 244, 261, 266], 'acute': [9, 262], 'radiation-induced': [10, 277], 'heart': [11, 278], 'damage': [12], '(RIHD)': [13], 'by': [14, 151, 163, 264], 'inhibiting': [15], 'activation': [17, 267], 'of': [18, 67, 77, 84, 105, 122, 128, 176, 183, 191, 211, 247, 268], 'NF-κB': [19, 129, 269], 'and': [20, 41, 53, 141, 146, 154, 188, 243, 250, 270], 'its': [21, 271], 'downstream': [22, 272], 'signaling': [23], 'pathways': [24], 'in': [25, 195, 214, 225, 237], 'rat': [26], 'models.\r\n\r\n\r\nMethods\r\nTwenty-one': [27], 'male': [28], 'adult': [29], 'Sprague-Dawley': [30], '(SD)': [31], 'rats': [32, 58], 'were': [33, 108, 148, 252], 'randomly': [34], 'divided': [35], 'into': [36], 'blank': [38], 'control,': [39], 'irradiation': [40, 44, 52, 55, 73, 172, 198, 228, 239], 'PDTC': [42, 78], 'plus': [43], 'groups': [45], '(n=7': [46], 'for': [47, 96], 'each': [48], 'group).': [49], 'In': [50, 70], 'PDTC+': [54, 72, 197, 227], 'groups,': [56], 'received': [59], '6': [60], 'MV': [61], 'X-ray': [62], 'at': [63, 81], 'a': [64, 82], 'single': [65], 'fraction': [66, 120], '20.0': [68], 'Gy.': [69], 'group,': [74, 173], 'intraperitonal': [75], 'injection': [76], 'was': [79, 113, 161, 179, 186, 193, 230], 'administered': [80], 'dose': [83], '120': [85], 'mg/kg': [86], 'body': [87], 'weight,': [88], '30': [89], 'minutes': [90], 'prior': [91], 'to': [92, 115, 255], 'radiation,': [93], 'once': [94], 'daily': [95], '1-14': [97], 'days.': [98], 'On': [99], '14th': [101], 'day,': [102], 'pathological': [103], 'changes': [104], 'myocardial': [106, 123, 177], 'tissue': [107, 137, 283], 'observed.': [109], 'Masson’s': [110, 200], 'trichrome': [111, 201], 'staining': [112, 166, 202], 'performed': [114], 'calculate': [116], 'collagen': [118, 142, 212], 'volume': [119], '(CVF)': [121], 'cells.': [124], 'The': [125], 'expression': [126, 245], 'levels': [127, 246], 'family': [130], 'members': [131], 'including': [132], 'p50,': [133], 'p65,': [134], 'HIF-1α,': [135], 'connective': [136], 'growth': [138, 284], 'factor': [139, 285], '(CTGF)': [140], 'type': [143], '1(COL-1)': [144], 'proteins': [145], 'mRNA': [147, 251], 'quantitatively': [149], 'measured': [150], 'Western': [152], 'blot': [153], 'quantitative': [155], 'real-time': [156], 'PCR': [157], '(qPCR).': [158], 'Statistical': [159], 'analysis': [160, 219], 'conducted': [162], 'using': [164], 't-test.\r\n\r\n\r\nResults\r\nHE': [165], 'demonstrated': [167, 220], 'that': [168, 204, 221], 'compared': [169, 234], 'with': [170, 235], 'severity': [175], 'edema': [178], 'alleviated,': [180], 'infiltration': [182], 'inflammatory': [184], 'cells': [185], 'mitigated': [187], 'quantity': [190], 'fibroblasts': [192], 'reduced': [194], 'group.': [199], 'revealed': [203], 'PDCT': [205], 'intervention': [206], 'could': [207], 'decrease': [208, 256], 'deposition': [210], 'fiber': [213], 'interstitial': [216], 'tissues.': [217], 'Semi-quantitative': [218], 'CVF': [223], 'value': [224], 'group': [229, 240], '(9.99±0.32)%,': [231], 'significantly': [232], 'lower': [233], '(22.05±0.21)%': [236], '(P': [241, 257], '0.05),': [242], 'COL-1': [248], 'protein': [249], 'equally': [253], 'inclined': [254], '0.05).\r\n\r\n\r\nConclusion\r\nPDTC': [258], 'alleviate': [260], 'RIHD': [263], 'suppressing': [265], 'HIF-1α': [273], 'transcription.\r\n\r\n\r\nKey': [274], 'words:': [275], '\r\nAcute': [276], 'damage;\xa0Nuclear': [279], 'factor-κB;\xa0Pyrrolidine': [280], 'dithiocarbamate;\xa0Hypoxia-inducible': [281], 'factor-1α;\xa0Connective': [282]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029653290', 'counts_by_year': [], 'updated_date': '2024-12-15T08:15:30.367027', 'created_date': '2020-06-05'}