Title: The diagnostic significance of detecting antinuclear antibody series and complement for patients with lupus nephritis
Abstract: Objective
To explore the diagnostic significance of detecting antinuclear antibody (ANA)series and complement for patients with lupus nephritis (LN) of systemic lupus erythematosus (SLE).
Methods
ANA was detected by indirect immunity fluorescent method. ANA series were detected by EUROIMMUN blotting.Complements (C3 and C4) of 1699 SLE patients and 120 healthy controls were detected by nephelometry.
Results
Among 1699 SLE patients, the positive rate of ANA was 97.4% in 921 patients with LN, while the positive rate of ANA was 98.2% in 778 patients without nephritis.There was significant difference between patients and controls (r=0.983, P=0.001). In patients with LN, the positive rate of anti-histone, -nucleosome and –dsDNA antibodies (3-pos) was 49.3%, 59.8%, and 63.3%, respectively.The positive rate of the corresponding antibodies in patients with on nephritis was 21.5%, 35%, and 47.9%, respectively. The difference between patients with and without nephritis was significant (r=0.452, P=0.007). The positive rate of anti-mitochondria-2 and anti-centromere was statistically difference between the two groups of patients (r=0.291, P=0.015). The C3 and C4 levels of 3-pos LN patients were significantly lower than that of non 3-pos patients (r=0.583, P=0.009).
Conclusion
Combined detection of ANA series and complement C3 and C4 is important for the clinical diagnosis of SLE with LN, and it may provide information for evaluating the prognosis of SLE patients.
Key words:
Systemie lupus erythematosus; Lupus nephritis; Antinuclear antibody series; C3; C4
Publication Year: 2017
Publication Date: 2017-07-05
Language: en
Type: article
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