Title: The Association of Anti-C1q Antibody with Disease Activity and Lupus Nephritis in Patients with SLE
Abstract: Objective To investigate the association of anti-C1q antibody with disease activity and lupus nephritis in patients with systemic lupus erythematosus(SLE). Methods The serum Level of anti-C1q antibody was determined in 35 patients with SLE by ELISA. The correlation between anti-C1q level and other disease activity parameters, such as SLEDAI score, anti-dsDNA antibody, C3, C4 and CH50 levels, was analyzed. Results Anti-C1q antibody was positive in 51.4% of patients with SLE, the positive rates in patients with active nephritis and without one was 77.8%(14/18) and 42.3%(22/52), respectively, and that was significantly higher in the former than in the later(P0.01). Serum levels of anti-C1q antibody were significantly higher in active SLE patients compared with inactive SLE patients, and were positively correlated with SLEDAI score, and the levels of anti-dsDNA antibody and CRP, but were negatively correlated with C3,C4 and CH50 concentrations. The positive rates of anti-C1q antibody, anti-dsDNA antibody and both were significantly higher in patients with active nephritis than those in patients without active nephritis. Conclusion The levels of anti-C1q antibodies in SLE patients were closely related to the disease activity. The detection of both anti-C1q antibody and anti-dsDNA antibody is a relatively specific index for active lupus nephritis, and the absence of both may be a valuable diagnostic means of excluding active lupus nephritis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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