Title: Efficacy and safety of alizarin combined with standard anti-tuberculosis therapy in treatment of multidrug-resistant pulmonary tuberculosis
Abstract: Objective
To evaluate the clinical efficacy and adverse reactions of alizarin combined with anti-tuberculosis therapy for multidrug resistant pulmonary tuberculosis (MDR-PTB).
Methods
A total of 200 confirmed MDR-PTB patients admitted in the Affiliated Hospital of Hangzhou Normal University during June 2013 and June 2015 were enrolled in the study. Patients were randomly divided into study group and control group (100 in each). Both groups were given standard anti-tuberculosis treatment for 8 months, and additional alizarin was given to study group. Chi-square test was used to assess the differences in clinical efficacy, sputum negative conversion rate, cavity closure and lesion absorption rate, as well as the incidence of adverse reactions between two groups(including patients categorized according to TCM syndrome).
Results
There were 39 markedly effective cases, 51 improved cases, 10 ineffective cases in study group, and 22 markedly effective cases, 35 improved cases, 43 ineffective cases in the control group. The total effective rate in study group was significantly higher than that in control group (90% vs. 57%, χ2=28.262, P 0.05). There was no significant difference in sputum negative conversion rate between two groups (76% vs. 55%, χ2=2.190, P>0.05). The cavity closure and lesion absorption rate in study group (91%) was significantly higher than that in the control group (54%, χ2=38.294, P<0.01). The adverse reaction rate in study group was 27%, which was significantly lower than that in control group (66%, χ2=30.570, P<0.01).
Conclusion
Alizarin in combination with standard anti-tuberculosis therapy can improve the clinical efficacy and reduce adverse reactions in treatment of MDR-PTB.
Key words:
Tuberculosis, pulmonary; Drugs, Chinese herbal; Alizarin; Drug resistance; Treatment outcome
Publication Year: 2016
Publication Date: 2016-06-28
Language: en
Type: article
Access and Citation
Cited By Count: 1
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