Title: The therapeutic effect of moxifloxacin and levofloxacin on multiple drug resistant pulmonary tuberculosis
Abstract: Objective To compare and evaluate the therapeuticeffect and safety of moxifloxacin on multiple drug resistant pulmonary tuberculosis(MDR-PTB).Methods 81 patients with MDR-PTB were randomlydivided into trial group and control group.The patients in trial group were treated with moxifloxacin containing regimen;the patients in control group were treated with sparfloxacin-containing regimen,with a treatment course of 12 months forboth groups.Results At the end of the treatment course,36 patients in trial group and 35 patients in control group could be evaluated.In full of 2 and 3 months,the sputums negative conversion rates were 75%,80.3% in trialgroup,which were significantly higher than 51.4%,60.0% i control group(P0.05),Four months later,the sputum negativeconversion rates in trial group were higher than those of control group,but there was no significant difference between the two groups(P0.05).At end of treatment course,the sputums negative conversion rate,focus absorption rate and cavity closing rate were 91.7%,88.9%,54.5% respectively in trial group,which were significantly higher than 82.9%,80.0.%,40.6%in control group(P0.05),but theree were no significant differences between two groups(P0.05).Adverse reaction intrial group was 15.4%,which was significantly lower than 35.0% in control group(P0.05).Conclusion Moxiflocacin-containing regimen is effective and safe drug in the treatment of MDR-PTB.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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Cited By Count: 1
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