Publication Information

{'id': 'https://openalex.org/W3029044821', 'doi': 'https://doi.org/10.3760/cma.j.issn.1005-1015.2015.02.012', 'title': 'The effects and mechanisms of G protein-coupled receptor 91 on blood-retinal barrier in diabetic rats', 'display_name': 'The effects and mechanisms of G protein-coupled receptor 91 on blood-retinal barrier in diabetic rats', 'publication_year': 2015, 'publication_date': '2015-03-25', 'ids': {'openalex': 'https://openalex.org/W3029044821', 'doi': 'https://doi.org/10.3760/cma.j.issn.1005-1015.2015.02.012', 'mag': '3029044821'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN511434201502/286472.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764748524', 'display_name': 'Zhonghua yandibing zazhi', 'issn_l': '1005-1015', 'issn': ['1005-1015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical 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'MAPK/ERK pathway', 'level': 3, 'score': 0.4245895}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42387742}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.41618317}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4097708}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40636405}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37293935}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 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'display_name': 'Zhonghua yandibing zazhi', 'issn_l': '1005-1015', 'issn': ['1005-1015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.78, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3203786091', 'https://openalex.org/W3140358764', 'https://openalex.org/W3032474110', 'https://openalex.org/W3031290628', 'https://openalex.org/W3030824595', 'https://openalex.org/W3029957996', 'https://openalex.org/W3029475401', 'https://openalex.org/W3029462488', 'https://openalex.org/W3028832593', 'https://openalex.org/W3024298719', 'https://openalex.org/W3013489948', 'https://openalex.org/W3011100988', 'https://openalex.org/W3005317081', 'https://openalex.org/W3000529316', 'https://openalex.org/W2996800546', 'https://openalex.org/W2980645727', 'https://openalex.org/W2385385377', 'https://openalex.org/W2370296765', 'https://openalex.org/W2336223862', 'https://openalex.org/W2078164302'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 59, 78, 109, 147, 181, 186, 198, 211, 215, 240, 252, 258, 274, 299, 313, 340, 356, 366, 379, 388, 392, 398], 'effects': [3], 'and': [4, 26, 49, 140, 165, 169, 173, 183, 246, 287, 305, 312, 345, 365, 391], 'mechanisms': [5], 'of': [6, 21, 63, 67, 82, 96, 111, 125, 149, 185, 201, 214, 255, 296, 302, 331, 342, 358, 375, 381, 394], 'G': [7], 'protein-coupled': [8], 'receptor': [9], '91': [10], '(GPR91)': [11], 'on': [12], 'blood-retinal': [13], 'barrier': [14], '(BRB)': [15], 'in': [16, 38, 225, 243, 251, 262, 269, 277, 316, 383], 'diabetic': [17, 90, 119, 384], 'rats.\r\n\r\n\r\nMethods\r\nA': [18], 'lentiviral': [19, 103, 131], 'vector': [20], 'shRNA': [22, 28, 102, 364, 377], 'targeting': [23], 'rat': [24], 'GPR91': [25, 206, 223, 325, 363, 376, 386], 'scrambled': [27, 101], 'were': [29, 36, 44, 143, 177, 348], 'constructed.': [30], 'Healthy': [31], 'male': [32], 'Sprague-Dawley': [33], '(SD)': [34], 'rats': [35, 43, 60, 79, 91, 120], 'selected': [37], 'this': [39], 'study.': [40], 'The': [41, 294, 329], '60': [42], 'randomized': [45], 'into': [46], '4': [47], 'groups': [48], 'treated': [50], 'as': [51], 'follows:': [52], '(1)': [53], 'control': [54], 'group': [55, 74, 86, 115], '(Group': [56, 75, 87, 116], 'A,': [57, 339], 'n=15),': [58, 77, 89, 118], 'received': [61, 80, 92, 121], 'injections': [62, 81], 'an': [64, 93, 122], 'equal': [65], 'volume': [66], '0.1%': [68], 'citrate': [69], 'buffer;': [70], '(2)': [71], 'streptozocin': [72], '(STZ)': [73], 'B,': [76], 'STZ;': [83], '(3)': [84], 'LV.shScrambled': [85], 'C,': [88], 'intravitreal': [94, 123, 137, 373], 'injection': [95, 124, 374], '1': [97, 126], 'μl': [98, 127], '1×108': [99, 128], 'TU/ml': [100, 129], 'particles': [104], 'at': [105], '2': [106], 'weeks': [107, 135], 'after': [108, 136, 323], 'induction': [110], 'diabetes;': [112], '(4)': [113], 'LV.shGPR91': [114], 'D,': [117], 'pGCSIL-GFP-shGPR91': [130], 'particles.': [132], 'At': [133], '12': [134], 'injection,': [138], 'immunohistochemistry': [139], 'Western': [141, 219, 332], 'blot': [142, 220, 333], 'used': [144, 178, 195], 'to': [145, 179, 196, 210], 'assess': [146, 180], 'expression': [148, 224, 315], 'GPR91,': [150], 'p-extracellular': [151], 'signal-regulated': [152], 'kinase(ERK)1/2,': [153], 't-ERK1/2,': [154], 'p-Jun': [155], 'N-terminal': [156], 'kinase': [157, 163], '(JNK),': [158], 't-JNK,': [159], 'p-p38': [160, 346], 'mitogen-activated': [161], 'protein': [162, 199], '(MAPK)': [164], 't-p38': [166], 'MAPK.': [167], 'Haematoxylin': [168], 'eosin': [170], '(HE)': [171], 'staining': [172, 203, 237], 'Evans': [174, 270], 'blue': [175, 271], 'dye': [176, 272], 'structure': [182], 'function': [184], 'retinal': [187], 'vessel.': [188], 'Immunohistochemistry': [189], 'enzyme-linked': [190], 'immunosorbent': [191], 'assay': [192], '(ELISA)': [193], 'was': [194, 207, 266, 289, 319, 360, 368], 'test': [197], 'level': [200], 'VEGF.\r\n\r\n\r\nResults\r\nImmunohistochemistry': [202], 'showed': [204, 221, 238, 298], 'that': [205, 222, 239, 273, 335], 'predominantly': [208], 'localized': [209], 'cell': [212, 217], 'bodies': [213], 'ganglion': [216], 'layer.': [218], 'Group': [226, 232, 244, 263, 278, 285, 303, 310, 317, 338], 'D': [227, 279, 318], 'decreased': [228, 280], 'significantly': [229, 320, 349], 'compared': [230, 283, 308, 336], 'with': [231, 284, 309, 337], 'C': [233, 247, 286, 306], '(F=39.31,': [234], 'P<0.01).': [235], 'HE': [236], 'retina': [241], 'tissue': [242], 'B': [245, 304], 'developed': [248], 'telangiectatic': [249, 259], 'vessels': [250, 260], 'inner': [253], 'layer': [254], 'retina,': [256], 'while': [257], 'attenuated': [261, 378], 'D.': [264], 'It': [265], 'also': [267], 'demonstrated': [268], 'microvascular': [275], 'leakage': [276, 380, 393], 'by': [281, 362], '(33.8±4.11)%': [282], 'there': [288], 'significant': [290, 370], 'difference': [291, 367], '(F=30.35,': [292], 'P<0.05).': [293, 328, 354], 'results': [295, 330], 'ELISA': [297], 'VEGF': [300, 314, 389], 'secretion': [301], 'increased': [307], 'A': [311], 'down': [321], 'regulated': [322, 387], 'silencing': [324], 'gene': [326], '(F=253.15,': [327], 'indicated': [334], 'expressions': [341], 'p-ERK1/2,': [343], 'p-JNK': [344], 'MAPK': [347], 'upregulated': [350], '(q=6.38,': [351], '2.94,': [352], '3.45;': [353], 'Meanwhile,': [355], 'activation': [357], 'ERK1/2': [359, 399], 'inhibited': [361], 'statistically': [369], '(F=22.50,': [371], 'P<0.05).\r\n\r\n\r\nConclusions\r\nThe': [372], 'BRB': [382, 395], 'rats.': [385], 'release': [390], 'possibly': [396], 'through': [397], 'signaling': [400], 'pathway.\r\n\r\n\r\nKey': [401], 'words:': [402], '\r\nDiabetic': [403], 'retinopathy/physiopathology;\xa0RNA,': [404], 'small': [405], 'interfering;\xa0Receptors,': [406], 'G-protein-coupled;\xa0Vascular': [407], 'Endothelial': [408], 'Growth': [409], 'Factors;\xa0p38': [410], 'Mitogen-Activated': [411], 'Protein': [412], 'Kinases;\xa0Animal': [413], 'experimentation': [414]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029044821', 'counts_by_year': [], 'updated_date': '2024-12-12T08:54:20.458287', 'created_date': '2020-06-05'}