Title: Effects of ligustrazine on the contraction of isolated rabbit corpus caverno sum strips
Abstract:Objective To investigate the role and mechanism of ligustrazine on relaxing the isolated rabbit corpus cavernosum tissue. Methods The relaxant effects of ligustrazine on corpus cavernosum were observe...Objective To investigate the role and mechanism of ligustrazine on relaxing the isolated rabbit corpus cavernosum tissue. Methods The relaxant effects of ligustrazine on corpus cavernosum were observed by using experimental method of smooth muscle strips. Concentration-responses to PE and KC1 were recorded. Results Ligustrazine concentration-dependently depressed the contraction response to PE. The maximum percentage relaxation of cavernosal strips by ligustrazine was (74.1±6.2)% [ compared with control: (21.9±5.6)%, P0.01 ]. Ligustrazine concentration-dependently inhibits the amplitude of the contraction induced by cumulative doses of PE and KC1. Conclusion Ligustrazine significantly relaxes the cavernosal muscle contraction induced by PE in vitro. The results suggested that ligustrazine inhibit calcium ion influx.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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