Publication Information

{'id': 'https://openalex.org/W3013601935', 'doi': 'https://doi.org/10.1085/jgp.202012619', 'title': 'Roles for the SNAP25 linker domain in the fusion pore and a dynamic plasma membrane SNARE “acceptor” complex', 'display_name': 'Roles for the SNAP25 linker domain in the fusion pore and a dynamic plasma membrane SNARE “acceptor” complex', 'publication_year': 2020, 'publication_date': '2020-07-28', 'ids': {'openalex': 'https://openalex.org/W3013601935', 'doi': 'https://doi.org/10.1085/jgp.202012619', 'mag': '3013601935', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32722752', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7478873'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1085/jgp.202012619', 'pdf_url': 'https://rupress.org/jgp/article-pdf/152/9/e202012619/1047911/jgp_202012619.pdf', 'source': {'id': 'https://openalex.org/S168548653', 'display_name': 'The Journal of General Physiology', 'issn_l': '0022-1295', 'issn': ['0022-1295', '1540-7748'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://rupress.org/jgp/article-pdf/152/9/e202012619/1047911/jgp_202012619.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049206589', 'display_name': 'Ronald W. Holz', 'orcid': 'https://orcid.org/0000-0002-6945-7805'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ronald W. Holz', 'raw_affiliation_strings': ['Department of Pharmacology, University of Michigan, Ann Arbor, MI'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Michigan, Ann Arbor, MI', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043304951', 'display_name': 'Mary A. Bittner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mary A. Bittner', 'raw_affiliation_strings': ['Department of Pharmacology, University of Michigan, Ann Arbor, MI'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Michigan, Ann Arbor, MI', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5049206589'], 'corresponding_institution_ids': ['https://openalex.org/I27837315'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.223, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.476184, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '152', 'issue': '9', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/snap25', 'display_name': 'SNAP25', 'score': 0.9618095}, {'id': 'https://openalex.org/keywords/snare-complex', 'display_name': 'SNARE complex', 'score': 0.7228286}, {'id': 'https://openalex.org/keywords/vesicle-fusion', 'display_name': 'Vesicle fusion', 'score': 0.6002973}, {'id': 'https://openalex.org/keywords/linker', 'display_name': 'Linker', 'score': 0.5082135}, {'id': 'https://openalex.org/keywords/palmitoylation', 'display_name': 'Palmitoylation', 'score': 0.49516454}, {'id': 'https://openalex.org/keywords/synaptobrevin', 'display_name': 'Synaptobrevin', 'score': 0.44379464}], 'concepts': [{'id': 'https://openalex.org/C134499376', 'wikidata': 'https://www.wikidata.org/wiki/Q14897641', 'display_name': 'SNAP25', 'level': 5, 'score': 0.9618095}, {'id': 'https://openalex.org/C2908790754', 'wikidata': 'https://www.wikidata.org/wiki/Q279694', 'display_name': 'SNARE complex', 'level': 4, 'score': 0.7228286}, {'id': 'https://openalex.org/C103038307', 'wikidata': 'https://www.wikidata.org/wiki/Q6556360', 'display_name': 'Lipid bilayer fusion', 'level': 3, 'score': 0.62525177}, {'id': 'https://openalex.org/C196330066', 'wikidata': 'https://www.wikidata.org/wiki/Q7923216', 'display_name': 'Vesicle fusion', 'level': 5, 'score': 0.6002973}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5488735}, {'id': 'https://openalex.org/C2780557392', 'wikidata': 'https://www.wikidata.org/wiki/Q523796', 'display_name': 'Linker', 'level': 2, 'score': 0.5082135}, {'id': 'https://openalex.org/C146727910', 'wikidata': 'https://www.wikidata.org/wiki/Q501620', 'display_name': 'Palmitoylation', 'level': 4, 'score': 0.49516454}, {'id': 'https://openalex.org/C175969161', 'wikidata': 'https://www.wikidata.org/wiki/Q323426', 'display_name': 'Exocytosis', 'level': 3, 'score': 0.4895309}, {'id': 'https://openalex.org/C148785051', 'wikidata': 'https://www.wikidata.org/wiki/Q671136', 'display_name': 'Synaptic vesicle', 'level': 4, 'score': 0.46633434}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.44849327}, {'id': 'https://openalex.org/C2777029164', 'wikidata': 'https://www.wikidata.org/wiki/Q82452579', 'display_name': 'Synaptobrevin', 'level': 5, 'score': 0.44379464}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43917626}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.4083217}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35119504}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.33384824}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25639683}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.05697319}, {'id': 'https://openalex.org/C2779201268', 'wikidata': 'https://www.wikidata.org/wiki/Q186474', 'display_name': 'Cysteine', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C111919701', 'wikidata': 'https://www.wikidata.org/wiki/Q9135', 'display_name': 'Operating system', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005089', 'descriptor_name': 'Exocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008561', 'descriptor_name': 'Membrane Fusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050825', 'descriptor_name': 'Synaptosomal-Associated Protein 25', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050765', 'descriptor_name': 'Qa-SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050683', 'descriptor_name': 'R-SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050825', 'descriptor_name': 'Synaptosomal-Associated Protein 25', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1085/jgp.202012619', 'pdf_url': 'https://rupress.org/jgp/article-pdf/152/9/e202012619/1047911/jgp_202012619.pdf', 'source': {'id': 'https://openalex.org/S168548653', 'display_name': 'The Journal of General Physiology', 'issn_l': '0022-1295', 'issn': ['0022-1295', '1540-7748'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478873', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202003.0401.v1', 'pdf_url': 'https://www.preprints.org/manuscript/202003.0401/v1/download', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32722752', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1085/jgp.202012619', 'pdf_url': 'https://rupress.org/jgp/article-pdf/152/9/e202012619/1047911/jgp_202012619.pdf', 'source': {'id': 'https://openalex.org/S168548653', 'display_name': 'The Journal of General Physiology', 'issn_l': '0022-1295', 'issn': ['0022-1295', '1540-7748'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01-170553'}], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1543112938', 'https://openalex.org/W1822252127', 'https://openalex.org/W1990976146', 'https://openalex.org/W1992294030', 'https://openalex.org/W1996598000', 'https://openalex.org/W2026862088', 'https://openalex.org/W2035145343', 'https://openalex.org/W2040025072', 'https://openalex.org/W2048465987', 'https://openalex.org/W2052999464', 'https://openalex.org/W2057518135', 'https://openalex.org/W2059637730', 'https://openalex.org/W2060384627', 'https://openalex.org/W2079405491', 'https://openalex.org/W2085829343', 'https://openalex.org/W2086696756', 'https://openalex.org/W2093160716', 'https://openalex.org/W2106303690', 'https://openalex.org/W2106431604', 'https://openalex.org/W2121079700', 'https://openalex.org/W2137679385', 'https://openalex.org/W2146650565', 'https://openalex.org/W2149231882', 'https://openalex.org/W2149451120', 'https://openalex.org/W2200436150', 'https://openalex.org/W2468606323', 'https://openalex.org/W2922164845', 'https://openalex.org/W2925111307'], 'related_works': ['https://openalex.org/W4213361830', 'https://openalex.org/W4211059813', 'https://openalex.org/W2941374900', 'https://openalex.org/W2384580589', 'https://openalex.org/W2309769689', 'https://openalex.org/W2159469027', 'https://openalex.org/W2069890177', 'https://openalex.org/W2056446815', 'https://openalex.org/W1994491721', 'https://openalex.org/W1587126988'], 'abstract_inverted_index': {'Central': [0], 'to': [1, 39, 45, 55, 148], 'the': [2, 10, 19, 28, 41, 75, 78, 82, 87, 132, 138, 149, 156, 159, 163, 166, 169, 190, 201, 206], 'exocytotic': [3], 'release': [4], 'of': [5, 12, 77, 86, 94, 158, 162, 168], 'hormones': [6], 'and': [7, 26, 32, 182, 198, 200], 'neurotransmitters': [8], 'is': [9, 37, 54], 'interaction': [11, 36], 'four': [13], 'SNARE': [14, 84, 193], 'motifs': [15, 85], 'in': [16, 101, 129, 143, 165], 'proteins': [17], 'on': [18, 27, 69], 'secretory': [20], 'granule/synaptic': [21], 'vesicle': [22, 135], 'membrane': [23, 30, 136, 140, 171, 192], '(synaptobrevin/VAMP,': [24], 'v-SNARE)': [25], 'plasma': [29, 139, 170, 191], '(syntaxin': [31], 'SNAP25,': [33], 't-SNAREs).': [34], 'The': [35], 'thought': [38], 'bring': [40], 'opposing': [42], 'membranes': [43], 'together': [44, 131, 179], 'enable': [46], 'fusion.': [47, 214], 'An': [48], 'underlying': [49], 'motivation': [50], 'for': [51, 91, 98, 175], 'this': [52], 'Viewpoint': [53], 'synthesize': [56], 'from': [57, 185], 'recent': [58, 71], 'diverse': [59], 'studies': [60, 184], 'possible': [61], 'new': [62], 'insights': [63], 'about': [64], 'these': [65], 'events.': [66], 'We': [67], 'focus': [68], 'a': [70, 110, 125], 'paper': [72], 'that': [73, 121, 189], 'demonstrates': [74], 'importance': [76, 157], 'linker': [79, 164], 'region': [80], 'joining': [81], 'two': [83], 'neuronal': [88], 't-SNARE': [89, 172], 'SNAP25': [90, 197], 'maintaining': [92], 'rates': [93], 'secretion': [95], 'with': [96, 137, 180, 205], 'roles': [97], 'distinct': [99], 'segments': [100], 'speeding': [102], 'fusion': [103, 117, 150], 'pore': [104, 118], 'expansion.': [105], 'Remarkably,': [106], 'lipid-perturbing': [107], 'agents': [108], 'rescue': [109], 'palmitoylation-deficient': [111], 'mutant': [112], 'whose': [113], 'phenotype': [114], 'includes': [115], 'slow': [116], 'expansion,': [119], 'suggesting': [120], 'protein–protein': [122], 'interactions': [123, 146], 'have': [124], 'role': [126], 'not': [127], 'only': [128], 'bringing': [130], 'granule': [133], 'or': [134], 'but': [141], 'also': [142], 'orchestrating': [144], 'protein–lipid': [145], 'leading': [147], 'reaction.': [151], 'Unexpectedly,': [152], 'biochemical': [153], 'investigations': [154], 'demonstrate': [155], 'C-terminal': [160], 'domain': [161], 'formation': [167], '“acceptor”': [173], 'complex': [174, 195, 204], 'synaptobrevin2.': [176], 'This': [177], 'insight,': [178], 'biophysical': [181], 'optical': [183], 'other': [186], 'laboratories,': [187], 'suggests': [188], 'acceptor': [194], 'between': [196], 'syntaxin': [199], 'subsequent': [202], 'trans-SNARE': [203], 'v-SNARE': [207], 'synaptobrevin': [208], 'form': [209], 'within': [210], '100': [211], 'ms': [212], 'before': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3013601935', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-09T02:14:29.688814', 'created_date': '2020-04-03'}