Title: Death from, with, and without pulmonary embolism
Abstract: Sudden death can be the initial presentation of pulmonary embolism and early fatality is substantial among patients who present with haemodynamic instability [ [1] Konstantinides S.V. Meyer G. Becattini C. et al. ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020; 41: 543-603 Crossref PubMed Scopus (1473) Google Scholar , [2] Huisman M.V. Barco S. Cannegieter S.C. et al. Pulmonary embolism. Nat Rev Dis Primers. 2018; 4: 18028 Crossref PubMed Scopus (150) Google Scholar ]. Death from pulmonary embolism, namely with pulmonary embolism starting the chain of medical events leading to death, remains a major contributor to cardiovascular mortality in Europe [ [3] Barco S. Mahmoudpour S.H. Valerio L. et al. Trends in mortality related to pulmonary embolism in the European Region, 2000-15: analysis of vital registration data from the WHO Mortality Database. Lancet Respir Med. 2019; https://doi.org/10.1016/S2213-2600(19)30354-6 Abstract Full Text Full Text PDF PubMed Scopus (125) Google Scholar ] and the United States [ [4] Wendelboe A.M. Raskob G.E. Global Burden of Thrombosis Epidemiologic Aspects. Circulation Research. 2016; 118: 1340-1347 Crossref PubMed Scopus (487) Google Scholar ]. Raising general awareness, a broader implementation of available preventive and diagnostic strategies, better criteria to identify higher risk patients, and safer reperfusion regimens represent unmet needs to reduce global pulmonary embolism-related mortality [ [2] Huisman M.V. Barco S. Cannegieter S.C. et al. Pulmonary embolism. Nat Rev Dis Primers. 2018; 4: 18028 Crossref PubMed Scopus (150) Google Scholar , 5 Barco S. Vicaut E. Klok F.A. et al. Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials. Eur Respir J. 2018; 51 Crossref Scopus (26) Google Scholar , 6 Jimenez D. Lobo J.L. Fernandez-Golfin C. et al. Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. Thromb Haemost. 2016; 115: 827-834 Crossref PubMed Scopus (22) Google Scholar , 7 Hirsh J. Eikelboom J.W. Chan N.C Fifty years of research on antithrombotic therapy: achievements and disappointments. Eur J Intern Med. 2019; 70: 1-7 Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar , 8 Barco S. Konstantinides S.V. Optimizing the personalized, risk-adjusted management of pulmonary embolism: an integrated clinical trial programme. Hamostaseologie. 2019; 39: 117-127 Crossref PubMed Scopus (4) Google Scholar ]. A clear definition of pulmonary embolism-related death will improve our ability to interpret the results of epidemiological studies and put the utility of interventions into the right perspective [ [9] Kraaijpoel N. Tritschler T. Guillo E. Girard P. Le Gal G Definitions, adjudication, and reporting of pulmonary embolism-related death in clinical studies: a systematic review. J Thromb Haemost. 2019; 17: 1590-1607 Crossref PubMed Scopus (18) Google Scholar ]. Short and long-term mortality in elderly patients with suspected not confirmed pulmonary embolismEuropean Journal of Internal MedicineVol. 73PreviewPulmonary embolism (PE) is a leading cause of mortality [1] and both its incidence and mortality increase with age [2–4]. After pursuing Emergency Department (ED) diagnostic work-up, the prevalence of confirmed PE ranges between 10 and 35% [1,5,6]. Full-Text PDF
Publication Year: 2020
Publication Date: 2020-03-01
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 4
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