Title: Neuregulin-1 down-regulates expression of ErbB3 expression in hepatoma cell lines at the level of transcription
Abstract: Previous studies from our group showed that HCV reduces the expression of ErbB3 in its host cell. As a result of this, the expression of EGFR, which is crucial for the viral entry, is enhanced, which suggests that HCV uses this rearrangement of the ErbB family members to improve its ability to enter the cell. Further investigations identified the ligand of ErbB3 receptor Neuregulin-1 to be responsible for its down-regulation and consequently triggering this circuit. The aim of the present study was to analyze whether down-regulation of ErbB3 by Nrg-1 also occurs in other human hepatoma cell lines and cells of other species like primary mouse hepatocytes and to assess whether this occurs at a transcriptional or post-transcriptional level.
Publication Year: 2020
Publication Date: 2020-01-01
Language: en
Type: article
Indexed In: ['crossref']
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