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'https://openalex.org/W2416034881'], 'related_works': ['https://openalex.org/W4387617928', 'https://openalex.org/W2332694965', 'https://openalex.org/W2314194975', 'https://openalex.org/W2276082140', 'https://openalex.org/W2124421908', 'https://openalex.org/W2086114072', 'https://openalex.org/W2013561277', 'https://openalex.org/W1990254579', 'https://openalex.org/W1980141913', 'https://openalex.org/W1970446746'], 'abstract_inverted_index': {'ラット褐色細胞腫': [0], '(PC12細胞)': [1], 'からRT-PCR法を用いてErbB新規リガンドとそのアイソフォーム4種類を同定し,': [2], '成熟ラットの脳と胸腺で強く発現していることから': [3], 'neural-': [4], 'and': [5], 'thymus-derived': [6], 'activator': [7], 'for': [8], 'ErbB': [9], 'kinases': [10], '(NTAK)': [11], 'と命名した.': [12], '予想される蛋白質構造は免疫グロブリン': [13], '(Ig)': [14], '様ドメイン,': [15], 'EGF様ドメイン,': [16], '疎水性ドメインからなりEGFファミリーのメンバーである': [17], 'neuregulin-1': [18], '(NRG-1)': [19], 'と同様のドメイン構造を示した.': [20], '哺乳動物細胞発現系を用いてこの蛋白質を精製したところ46kDaの糖蛋白質で,': [21], 'ヒト乳癌細胞株MDA-MB-453細胞を分化させた.': [22], 'NTAKはホモダイマーのErbB3,': [23], 'ErbB4には結合するがErbB1とErbB2には結合しなかった.': [24], 'しかし,': [25], 'これらのレセプターをヘテロダイマーで細胞表面上に発現させると,': [26], '構成する全てのレセプターでチロシンのリン酸化が観察された.': [27], 'このことは,': [28], 'NTAKが結合すると異なるErbBファミリーが二量体を形成し,': [29], '活性化してクロストークすることを示唆している.': [30], 'よって,': [31], 'NTAKは新しいEGFファミリーのメンバーでNRG-1様の機能を持っていることが明らかになった.': [32]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003229315', 'counts_by_year': [], 'updated_date': '2024-09-24T17:36:18.974189', 'created_date': '2016-06-24'}