Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2997241518', 'doi': 'https://doi.org/10.1021/acs.iecr.9b05847', 'title': 'Linking Engineered Gene Circuit Kinetic Modeling to Cellulose Biosynthesis Prediction in <i>Escherichia coli</i>: Toward Bioprocessing of Microbial Cell Factories', 'display_name': 'Linking Engineered Gene Circuit Kinetic Modeling to Cellulose Biosynthesis Prediction in <i>Escherichia coli</i>: Toward Bioprocessing of Microbial Cell Factories', 'publication_year': 2020, 'publication_date': '2020-01-03', 'ids': {'openalex': 'https://openalex.org/W2997241518', 'doi': 'https://doi.org/10.1021/acs.iecr.9b05847', 'mag': '2997241518'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.iecr.9b05847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S202680183', 'display_name': 'Industrial & Engineering Chemistry Research', 'issn_l': '0888-5885', 'issn': ['0888-5885', '1520-5045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1021/acs.iecr.9b05847', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064740443', 'display_name': 'Gizem Buldum', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gizem Buldum', 'raw_affiliation_strings': ['Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006373238', 'display_name': 'Argyro Tsipa', 'orcid': 'https://orcid.org/0000-0001-8793-1657'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Argyro Tsipa', 'raw_affiliation_strings': ['Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048473531', 'display_name': 'Athanasios Mantalaris', 'orcid': 'https://orcid.org/0000-0001-6183-0292'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}, {'id': 'https://openalex.org/I130701444', 'display_name': 'Georgia Institute of Technology', 'ror': 'https://ror.org/01zkghx44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130701444']}, {'id': 'https://openalex.org/I2802612298', 'display_name': 'The Wallace H. Coulter Department of Biomedical Engineering', 'ror': 'https://ror.org/02j15s898', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130701444', 'https://openalex.org/I150468666', 'https://openalex.org/I2802612298']}], 'countries': ['GB', 'US'], 'is_corresponding': True, 'raw_author_name': 'Athanasios Mantalaris', 'raw_affiliation_strings': ['Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom', 'Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, United States'], 'affiliations': [{'raw_affiliation_string': 'Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}, {'raw_affiliation_string': 'Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, United States', 'institution_ids': ['https://openalex.org/I130701444', 'https://openalex.org/I2802612298']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5048473531'], 'corresponding_institution_ids': ['https://openalex.org/I47508984', 'https://openalex.org/I130701444', 'https://openalex.org/I2802612298'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.236, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.444549, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '59', 'issue': '10', 'first_page': '4659', 'last_page': '4669'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10932', 'display_name': 'Microbial Metabolic Engineering and Bioproduction', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10932', 'display_name': 'Microbial Metabolic Engineering and Bioproduction', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10171', 'display_name': 'Biofuel production and bioconversion', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Gene Regulatory Network Analysis', 'score': 0.9614, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synthetic-biology', 'display_name': 'Synthetic Biology', 'score': 0.7731234}, {'id': 'https://openalex.org/keywords/bioprocess-engineering', 'display_name': 'Bioprocess engineering', 'score': 0.7182778}, {'id': 'https://openalex.org/keywords/metabolic-engineering', 'display_name': 'Metabolic Engineering', 'score': 0.4496742}, {'id': 'https://openalex.org/keywords/bacterial-cellulose', 'display_name': 'Bacterial Cellulose', 'score': 0.43369102}, {'id': 'https://openalex.org/keywords/rational-design', 'display_name': 'Rational design', 'score': 0.41506833}], 'concepts': [{'id': 'https://openalex.org/C4916135', 'wikidata': 'https://www.wikidata.org/wiki/Q4119055', 'display_name': 'Bioprocess', 'level': 2, 'score': 0.9728698}, {'id': 'https://openalex.org/C191908910', 'wikidata': 'https://www.wikidata.org/wiki/Q862838', 'display_name': 'Synthetic biology', 'level': 2, 'score': 0.7731234}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.74289286}, {'id': 'https://openalex.org/C61664519', 'wikidata': 'https://www.wikidata.org/wiki/Q864734', 'display_name': 'Bioprocess engineering', 'level': 2, 'score': 0.7182778}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.6384693}, {'id': 'https://openalex.org/C6350086', 'wikidata': 'https://www.wikidata.org/wiki/Q6822347', 'display_name': 'Metabolic engineering', 'level': 3, 'score': 0.4496742}, {'id': 'https://openalex.org/C152662350', 'wikidata': 'https://www.wikidata.org/wiki/Q815297', 'display_name': 'Systems biology', 'level': 2, 'score': 0.4460988}, {'id': 'https://openalex.org/C168170006', 'wikidata': 'https://www.wikidata.org/wiki/Q864699', 'display_name': 'Bioreactor', 'level': 2, 'score': 0.43590552}, {'id': 'https://openalex.org/C2779477270', 'wikidata': 'https://www.wikidata.org/wiki/Q4839982', 'display_name': 'Bacterial cellulose', 'level': 3, 'score': 0.43369102}, {'id': 'https://openalex.org/C53105671', 'wikidata': 'https://www.wikidata.org/wiki/Q14777816', 'display_name': 'Rational design', 'level': 2, 'score': 0.41506833}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.39837903}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3921911}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3442992}, {'id': 'https://openalex.org/C2779251873', 'wikidata': 'https://www.wikidata.org/wiki/Q80294', 'display_name': 'Cellulose', 'level': 2, 'score': 0.34275025}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.29302758}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2797947}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.14887968}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.099246174}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.iecr.9b05847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S202680183', 'display_name': 'Industrial & Engineering Chemistry Research', 'issn_l': '0888-5885', 'issn': ['0888-5885', '1520-5045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.iecr.9b05847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S202680183', 'display_name': 'Industrial & Engineering Chemistry Research', 'issn_l': '0888-5885', 'issn': ['0888-5885', '1520-5045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Industry, innovation and infrastructure', 'score': 0.67, 'id': 'https://metadata.un.org/sdg/9'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1549699363', 'https://openalex.org/W1560274396', 'https://openalex.org/W1578698661', 'https://openalex.org/W1599969036', 'https://openalex.org/W1604409283', 'https://openalex.org/W1912762964', 'https://openalex.org/W1918927381', 'https://openalex.org/W1966293504', 'https://openalex.org/W1969192942', 'https://openalex.org/W1976222094', 'https://openalex.org/W1982647911', 'https://openalex.org/W1982728774', 'https://openalex.org/W1987738095', 'https://openalex.org/W1988540551', 'https://openalex.org/W1991394444', 'https://openalex.org/W1993053283', 'https://openalex.org/W1999675984', 'https://openalex.org/W2007186776', 'https://openalex.org/W2010546547', 'https://openalex.org/W2016195587', 'https://openalex.org/W2024921867', 'https://openalex.org/W2025902887', 'https://openalex.org/W2027931717', 'https://openalex.org/W2030941759', 'https://openalex.org/W2031941431', 'https://openalex.org/W2041107214', 'https://openalex.org/W2045510002', 'https://openalex.org/W2048932465', 'https://openalex.org/W2053813135', 'https://openalex.org/W2061104439', 'https://openalex.org/W2062613044', 'https://openalex.org/W2066982641', 'https://openalex.org/W2088383307', 'https://openalex.org/W2101589741', 'https://openalex.org/W2107907052', 'https://openalex.org/W2111652881', 'https://openalex.org/W2112289062', 'https://openalex.org/W2127215672', 'https://openalex.org/W2129583379', 'https://openalex.org/W2141716034', 'https://openalex.org/W2150583791', 'https://openalex.org/W2156852846', 'https://openalex.org/W2164898811', 'https://openalex.org/W2165786088', 'https://openalex.org/W2169331722', 'https://openalex.org/W2169658509', 'https://openalex.org/W2254470084', 'https://openalex.org/W2303875941', 'https://openalex.org/W2328214874', 'https://openalex.org/W2330245166', 'https://openalex.org/W2335313871', 'https://openalex.org/W2520902279', 'https://openalex.org/W2595472100', 'https://openalex.org/W2761735146', 'https://openalex.org/W2769039398', 'https://openalex.org/W2796915089', 'https://openalex.org/W2801176390', 'https://openalex.org/W2989710086', 'https://openalex.org/W3099200196', 'https://openalex.org/W4241312916'], 'related_works': ['https://openalex.org/W614180819', 'https://openalex.org/W4240765630', 'https://openalex.org/W4236420500', 'https://openalex.org/W4230053016', 'https://openalex.org/W3015120333', 'https://openalex.org/W2908563846', 'https://openalex.org/W2512581390', 'https://openalex.org/W2070169729', 'https://openalex.org/W2054154997', 'https://openalex.org/W2022238394'], 'abstract_inverted_index': {'Microbial': [0], 'cell': [1, 33, 113, 138], 'factories': [2, 34], 'synthesize': [3], 'value-added': [4], 'products;': [5], 'their': [6, 142], 'bioprocessing': [7], 'with': [8], 'the': [9, 23, 45, 54, 60, 82, 95, 102, 105, 133], 'aid': [10], 'of': [11, 31, 62, 78, 81, 97, 104, 136], 'synthetic': [12, 130], 'and': [13, 19, 65, 76, 124, 129, 141], 'system': [14], 'biology': [15, 131], 'represents': [16], 'a': [17, 40, 108, 122], 'green': [18], 'sustainable': [20], 'alternative': [21], 'to': [22, 50, 68, 127], 'traditional': [24], 'chemical': [25], 'industry.': [26], 'Currently,': [27], 'bioprocess': [28, 51, 143], 'performance': [29], 'prediction': [30], 'microbial': [32, 69, 137], 'is': [35, 66, 121], 'limited.': [36], 'Herein,': [37], 'we': [38], 'present': [39], 'rational': [41], 'modeling': [42, 87], 'approach': [43, 88, 106, 126], 'linking': [44], 'designed': [46], 'engineered': [47, 55], 'gene': [48, 56, 74, 83], 'circuit': [49, 57], 'kinetics,': [52], 'whereby': [53], 'model': [58, 120], 'informs': [59], 'formulation': [61], 'product': [63], 'biosynthesis': [64, 112], 'coupled': [67], 'growth.': [70], 'We': [71, 100], 'achieve': [72], 'dynamic': [73], 'expression': [75], 'estimation': [77], 'enzyme': [79], 'synthesis': [80], 'circuit.': [84], 'Significantly,': [85], 'this': [86], 'considers': [89], 'plasmid': [90], 'stability,': [91], 'which': [92], 'may': [93], 'decrease': [94], 'productivity': [96], 'recombinant': [98], 'systems.': [99], 'demonstrate': [101], 'validity': [103], 'using': [107], 'bacterial': [109], 'cellulose': [110], '(BC)': [111], 'factory': [114, 139], 'in': [115], 'Escherichia': [116], 'coli.': [117], 'This': [118], 'kinetic': [119], 'practical': [123], 'complementary': [125], 'systems': [128, 140], 'for': [132], 'robust': [134], 'operation': [135], 'applications.': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2997241518', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-12-27T10:30:06.939026', 'created_date': '2020-01-10'}