Title: Microvascular Surgery: Coagulation, Fibrinolysis, and Principles for Antithrombotic Therapy
Abstract: This chapter describes the events which take place in the circulating blood starting at the time of surgery. The adhesion of platelets to collagen exposed by injury to the vascular endothelium constitutes the first response in hemostasis. The drop in the platelet count is partially related to blood loss and blood transfusions, to the aggregation of platelets and their trapping in various organs, and to a consumption of platelets in the traumatized area. In microvascular surgery, the aggregation of platelets to an exposed subendothelium may be severe enough to cause a technical failure. Since the platelets are unable to synthesize protein, the inhibition is irreversible; therefore, the effect lasts as long as the platelets live. Changes in the platelet activity occur after surgery and trauma. An increase in the fibrinolytic activity after surgery was noticed for the first time by R. G. Macfarlane in a patient who underwent a cholecystectomy.
Publication Year: 2019
Publication Date: 2019-06-13
Language: en
Type: book-chapter
Indexed In: ['crossref']
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