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'early': [6], 'and': [7, 46, 68, 92, 97, 126, 132, 149, 168], 'seriously': [8], 'in': [9, 71, 106, 116, 138, 154, 161], 'the': [10, 41, 56, 120, 123, 145, 151], 'progress': [11], 'of': [12, 43, 58, 122, 128, 142, 147], 'sepsis.': [13, 139, 180], 'Netrin-1': [14, 131], 'is': [15], 'demonstrated': [16], 'to': [17, 174], 'be': [18], 'an': [19], 'effective': [20], 'anti-inflammatory': [21], 'agent.': [22], 'However,': [23, 140], 'whether': [24], 'netrin-1': [25, 143], 'can': [26], 'relieve': [27], 'sepsis-induced': [28], 'ALI': [29, 160], 'remains': [30], 'unknown.': [31], 'MATERIAL': [32], 'AND': [33], 'METHODS:The': [34], 'sepsis': [35, 114, 162], 'rat': [36], 'model': [37, 75], 'was': [38, 76], 'built': [39], 'with': [40, 78, 119], 'method': [42], 'cecal': [44], 'ligation': [45], 'puncture': [47], '(CLP).': [48], 'The': [49, 82], 'tissue': [51], 'changes': [52], 'were': [53, 86, 100, 136], 'represented': [54], 'as': [55], 'results': [57], 'hematoxylin-eosin': [59], '(HE)': [60], 'staining,': [61], 'wet-to-dry': [62], '(W/D)': [63], 'ratio,': [64], 'Western': [65, 89, 103], 'blot': [66, 90, 104], 'analysis,': [67], 'immunohistochemistry.': [69], 'An': [70], 'vitro': [72], 'simulated': [77], 'LPS-induced': [79, 107], 'BEAS-2B': [80, 108, 155], 'cells.': [81, 109, 156], 'cell': [83], 'transfection': [84], 'effects': [85], 'evaluated': [87], 'by': [88, 102, 113, 179], 'analysis': [91, 105], 'RT-qPCR': [93], 'analysis.': [94], 'TNF-α,': [95], 'IL-1β,': [96], 'IL-6': [98], 'levels': [99, 146, 153], 'detected': [101], 'RESULTS:Obvious': [110], 'inflammation': [111, 148], 'caused': [112, 178], 'appeared': [115], 'tissues': [118], 'increase': [121], 'W/D': [124], 'ratio': [125], 'expression': [127], 'inflammatory': [129], 'cytokines.': [130], 'its': [133, 165], 'receptor': [134], 'UNC5B': [135, 152], 'reduced': [137], 'upregulation': [141], 'alleviated': [144], 'increased': [150], 'CONCLUSIONS:Netrin-1': [157], 'protects': [158], 'against': [159], 'rats': [163], 'through': [164], 'anti-inflammation': [166], 'effect': [167], 'may': [169], 'provide': [170], 'a': [171], 'novel': [172], 'treatment': [173], 'prevent': [175]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2982208563', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-18T17:09:11.098632', 'created_date': '2019-11-01'}