Publication Information

{'id': 'https://openalex.org/W2026862129', 'doi': 'https://doi.org/10.1006/bbrc.2001.5145', 'title': 'Downregulation of p21/WAF1 Expression by Thymidylate Synthase', 'display_name': 'Downregulation of p21/WAF1 Expression by Thymidylate Synthase', 'publication_year': 2001, 'publication_date': '2001-07-01', 'ids': {'openalex': 'https://openalex.org/W2026862129', 'doi': 'https://doi.org/10.1006/bbrc.2001.5145', 'mag': '2026862129', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11444825'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/bbrc.2001.5145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053760458', 'display_name': 'Evdokia Kastanos', 'orcid': 'https://orcid.org/0000-0002-0415-1610'}, 'institutions': [{'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Evdokia K. Kastanos', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, Bethesda, MD 20892, USA.'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012399743', 'display_name': 'Maria Zajac‐Kaye', 'orcid': 'https://orcid.org/0000-0001-8804-9076'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria Zajac-Kaye', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022984824', 'display_name': 'Phillip A. Dennis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Phillip A. Dennis', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5069843364', 'display_name': 'Carmen J. Allegra', 'orcid': 'https://orcid.org/0000-0001-6402-2709'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carmen J. Allegra', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.007, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.6362, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '285', 'issue': '2', 'first_page': '195', 'last_page': '200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11970', 'display_name': 'Molecular Biology Techniques and Applications', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.98170227}, {'id': 'https://openalex.org/C123321153', 'wikidata': 'https://www.wikidata.org/wiki/Q22676802', 'display_name': 'Thymidylate synthase', 'level': 4, 'score': 0.93146896}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5021596}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.4528164}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.45171267}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41835576}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41638616}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35989875}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22923595}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18679866}, {'id': 'https://openalex.org/C2780456651', 'wikidata': 'https://www.wikidata.org/wiki/Q238512', 'display_name': 'Fluorouracil', 'level': 3, 'score': 0.097700775}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.083836466}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.07983923}], 'mesh': [{'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013940', 'descriptor_name': 'Thymidylate Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002474', 'descriptor_name': 'Cell-Free System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050759', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p21', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016193', 'descriptor_name': 'G1 Phase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016158', 'descriptor_name': 'Genes, p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016196', 'descriptor_name': 'S Phase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013940', 'descriptor_name': 'Thymidylate Synthase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013940', 'descriptor_name': 'Thymidylate Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015032', 'descriptor_name': 'Zinc', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015032', 'descriptor_name': 'Zinc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/bbrc.2001.5145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11444825', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1498586399', 'https://openalex.org/W1590434810', 'https://openalex.org/W1594621311', 'https://openalex.org/W1621571238', 'https://openalex.org/W1833292963', 'https://openalex.org/W1970726343', 'https://openalex.org/W2013060968', 'https://openalex.org/W2015519364', 'https://openalex.org/W2042316019', 'https://openalex.org/W2060810889', 'https://openalex.org/W2083627679', 'https://openalex.org/W2097129108', 'https://openalex.org/W2100837269', 'https://openalex.org/W2113406475', 'https://openalex.org/W2115231119', 'https://openalex.org/W2122663153', 'https://openalex.org/W2128635872', 'https://openalex.org/W2142800802', 'https://openalex.org/W2144634347', 'https://openalex.org/W2150097377', 'https://openalex.org/W2167912001', 'https://openalex.org/W2168276925', 'https://openalex.org/W2168701969', 'https://openalex.org/W2314225431', 'https://openalex.org/W2409469058', 'https://openalex.org/W4241531133', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W4231887835', 'https://openalex.org/W3031205269', 'https://openalex.org/W3029889643', 'https://openalex.org/W2392930094', 'https://openalex.org/W2153582959', 'https://openalex.org/W2137989529', 'https://openalex.org/W2043125576', 'https://openalex.org/W2010366112', 'https://openalex.org/W1984994946', 'https://openalex.org/W1484903029'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026862129', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-15T23:37:03.426129', 'created_date': '2016-06-24'}