Aconitine induces cardiomyocyte damage by mitigating BNIP3‐dependent mitophagy and the TNFα‐NLRP3 signalling axis

Name: Work Video:
Duration: 3 min 30 s
Peng Fu; Nan Zhang; Chunting Wang; Xiaoyun Wang; Wei Huang; Cheng Peng; Gu He; Bo Han
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'diseases,': [18], 'including': [19], 'rheumatism,': [20], 'arthritis,': [21], 'bruises,': [22], 'fractures': [23], 'and': [24, 32, 50, 60, 75, 83, 86, 91, 104, 128, 145, 152], 'pains.': [25], 'However,': [26], 'many': [27], 'studies': [28], 'have': [29], 'reported': [30], 'cardiotoxicity': [31, 122], 'neurotoxicity': [33], 'caused': [34], 'by': [35, 68, 100, 125], 'aconitine,': [36], 'but': [37], 'detailed': [39], 'mechanism': [40], 'underlying': [41], "aconitine's": [42], 'effect': [43], 'on': [44, 56], 'these': [45], 'processes': [46], 'remains': [47], 'unclear.': [48], 'Materials': [49], 'methods': [51], 'The': [52], 'effects': [53], 'aconitine': [55, 124], 'inflammation,': [58], 'apoptosis': [59, 87, 127], 'viability': [61], 'H9c2': [63], 'rat': [64], 'cardiomyocytes': [65], 'were': [66], 'evaluated': [67], 'flow': [69], 'cytometry,': [70], 'Western': [71], 'blot,': [72], 'RNA': [73], 'sequencing': [74], 'bioinformatics': [76], 'analysis.': [77], 'Results': [78], 'Aconitine': [79], 'suppressed': [80, 120], 'cardiomyocyte': [81], 'proliferation': [82], 'induced': [84], 'inflammation': [85], 'in': [88, 110, 116], 'a': [89, 101, 136, 142], 'dose‐': [90], 'time‐dependent': [92], 'manner.': [93], 'These': [94], 'inflammatory': [95], 'damages': [96], 'could': [97], 'be': [98], 'reversed': [99], 'TNFα': [102, 143], 'inhibitor': [103, 144], 'BNIP3‐mediated': [105], 'mitophagy.': [106], 'Consistent': [107], 'with': [108], 'vitro': [111], 'results,': [112], 'overexpression': [113], 'BNIP3': [115, 146], 'heart': [117], 'tissue': [118], 'partially': [119], 'inhibiting': [126], 'NLRP3': [130], 'inflammasome.': [131], 'Conclusions': [132], 'Our': [133], 'findings': [134], 'lay': [135], 'foundation': [137], 'application': [140], 'to': [147], 'aconitine‐induced': [148], 'cardiac': [149], 'toxicity': [150], 'prevention': [151], 'therapy,': [153], 'thereby': [154], 'demonstrating': [155], 'potential': [156], 'further': [158], 'investigation.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2981902997', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 7}], 'updated_date': '2025-01-07T10:18:36.862515', 'created_date': '2019-11-01'}
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