Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2741510057', 'doi': 'https://doi.org/10.3785/j.issn.1008-9292.2017.02.14', 'title': '[Research progress on mechanism of Nix-mediated mitophagy].', 'display_name': '[Research progress on mechanism of Nix-mediated mitophagy].', 'publication_year': 2017, 'publication_date': '2017-01-25', 'ids': {'openalex': 'https://openalex.org/W2741510057', 'doi': 'https://doi.org/10.3785/j.issn.1008-9292.2017.02.14', 'mag': '2741510057', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28436637'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28436637', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089702300', 'display_name': 'Yanrong Zheng', 'orcid': 'https://orcid.org/0000-0001-6253-9835'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanrong Zheng', 'raw_affiliation_strings': ['College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016513445', 'display_name': 'Xiangnan Zhang', 'orcid': 'https://orcid.org/0000-0002-7603-7403'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiangnan Zhang', 'raw_affiliation_strings': ['College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100430427', 'display_name': 'Zhong Chen', 'orcid': 'https://orcid.org/0000-0003-4755-9357'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhong Chen', 'raw_affiliation_strings': ['College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. [email protected].'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. [email protected].', 'institution_ids': ['https://openalex.org/I76130692']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.042, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.190292, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '46', 'issue': '1', 'first_page': '92', 'last_page': '96'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atg8', 'display_name': 'ATG8', 'score': 0.63906825}], 'concepts': [{'id': 'https://openalex.org/C2779324830', 'wikidata': 'https://www.wikidata.org/wiki/Q1806192', 'display_name': 'Mitophagy', 'level': 4, 'score': 0.9979136}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.94079566}, {'id': 'https://openalex.org/C2777668072', 'wikidata': 'https://www.wikidata.org/wiki/Q2472777', 'display_name': 'Parkin', 'level': 4, 'score': 0.85125065}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.74524033}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.7084736}, {'id': 'https://openalex.org/C2780042272', 'wikidata': 'https://www.wikidata.org/wiki/Q27548992', 'display_name': 'ATG8', 'level': 4, 'score': 0.63906825}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47339618}, {'id': 'https://openalex.org/C98539663', 'wikidata': 'https://www.wikidata.org/wiki/Q220599', 'display_name': 'Cytosol', 'level': 3, 'score': 0.44967228}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.41805154}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36277387}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.24165365}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17123163}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.1610041}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0810602}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.056846738}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D063306', 'descriptor_name': 'Mitophagy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D063306', 'descriptor_name': 'Mitophagy', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071190', 'descriptor_name': 'Autophagy-Related Protein 8 Family', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000071190', 'descriptor_name': 'Autophagy-Related Protein 8 Family', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071186', 'descriptor_name': 'Beclin-1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000071186', 'descriptor_name': 'Beclin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063306', 'descriptor_name': 'Mitophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054730', 'descriptor_name': 'Protein Interaction Domains and Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28436637', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1523693806', 'https://openalex.org/W1627187635', 'https://openalex.org/W1873137731', 'https://openalex.org/W1935479846', 'https://openalex.org/W1968843321', 'https://openalex.org/W1972336737', 'https://openalex.org/W1984282920', 'https://openalex.org/W1995417238', 'https://openalex.org/W1998354357', 'https://openalex.org/W2001648286', 'https://openalex.org/W2008376982', 'https://openalex.org/W2018636808', 'https://openalex.org/W2028807366', 'https://openalex.org/W2033874071', 'https://openalex.org/W2034087770', 'https://openalex.org/W2034506209', 'https://openalex.org/W2038976751', 'https://openalex.org/W2043882563', 'https://openalex.org/W2047242847', 'https://openalex.org/W2049729563', 'https://openalex.org/W2062807784', 'https://openalex.org/W2067471739', 'https://openalex.org/W2067692987', 'https://openalex.org/W2069403245', 'https://openalex.org/W2082395741', 'https://openalex.org/W2086557228', 'https://openalex.org/W2099875422', 'https://openalex.org/W2100886460', 'https://openalex.org/W2103187359', 'https://openalex.org/W2108326484', 'https://openalex.org/W2110293180', 'https://openalex.org/W2127440157', 'https://openalex.org/W2131007152', 'https://openalex.org/W2132357771', 'https://openalex.org/W2138311396', 'https://openalex.org/W2144450295', 'https://openalex.org/W2160845673', 'https://openalex.org/W2164945122'], 'related_works': ['https://openalex.org/W3094078064', 'https://openalex.org/W3036585903', 'https://openalex.org/W2953588115', 'https://openalex.org/W2921505376', 'https://openalex.org/W2587560288', 'https://openalex.org/W2106876891', 'https://openalex.org/W2061633455', 'https://openalex.org/W2035756758', 'https://openalex.org/W1982520634', 'https://openalex.org/W1967888239'], 'abstract_inverted_index': {'Autophagy': [0], 'is': [1, 41], 'fundamental': [2], 'to': [3, 32, 87, 119], 'maintain': [4], 'cellular': [5], 'homeostasis.': [6], 'As': [7], 'one': [8], 'kind': [9], 'of': [10, 17, 24, 50, 71, 123], 'the': [11, 22, 48, 53], 'most': [12], 'well-studied': [13], 'selective': [14], 'autophagy,': [15], 'autophagy': [16, 98, 136], 'mitochondria': [18], '(mitophagy)is': [19], 'crucial': [20], 'for': [21, 45, 85, 97], 'clearance': [23], 'damaged': [25], 'mitochondria.': [26], 'Mitophagy': [27], 'dysfunction': [28], 'has': [29], 'been': [30], 'proved': [31], 'be': [33], 'closely': [34], 'associated': [35], 'with': [36, 80, 102, 117], 'many': [37], 'human': [38], 'diseases.': [39], 'Nix': [40, 72, 77, 91, 114], 'a': [42, 95, 111], 'key': [43], 'protein': [44, 84], 'mitophagy': [46, 59, 74], 'during': [47], 'maturation': [49], 'reticulocytes.': [51], 'However,': [52], 'detailed': [54], 'molecular': [55], 'mechanisms': [56], 'underlying': [57], 'Nix-mediated': [58], 'are': [60], 'not': [61], 'fully': [62], 'understood.': [63], 'This': [64], 'article': [65], 'summarizes': [66], 'three': [67], 'possible': [68], 'working': [69], 'models': [70], 'in': [73, 127, 131], 'induction.': [75], 'Firstly,': [76], 'can': [78, 92, 115], 'interplay': [79], 'Parkin,': [81], 'another': [82], 'important': [83], 'mitophagy,': [86], 'initiate': [88], 'mitophagy.': [89], 'Secondly,': [90], 'serve': [93], 'as': [94, 110], 'receptor': [96], 'machinery': [99], 'by': [100], 'interacting': [101], 'Atg8': [103], 'family': [104, 125], 'through': [105], 'its': [106], 'LIR': [107], 'motif.': [108], 'Finally,': [109], 'BH3-only': [112], 'protein,': [113], 'compete': [116], 'Beclin-1': [118, 130], 'bind': [120], 'other': [121], 'members': [122], 'Bcl-2': [124], 'resulting': [126], 'increased': [128], 'free': [129], 'cytosol,': [132], 'which': [133], 'further': [134], 'promotes': [135], 'flux.': [137]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2741510057', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-16T14:09:14.331481', 'created_date': '2017-08-08'}