Title: Effects of cadmium on calcium metablisms of ovariectomized rats
Abstract: Objective To investigate effects of cadmium on calcium metabolisms of ovariectomized rats.Methods Female Sprague Dawley rats aged 6 months were ovariectomized.The rats were administrated with cadmium at the dose of 0,50,100 and 200 mg/L in drinking water for 24 weeks.Urine and feces of 24 hours were collected after 6,12,18 and 24 weeks,respectively.Cadmium concentration in urine,blood and bone were measured by an atomic absorption spectrophotometer.And urinary β\-2 MG and serum estradiol were detected by RIA.The calcium contents in bone,urine and feces were assayed.Results Compared to the sham operation group,estradiol significantly declined in the ovariectomized rats.After cadmium administration,the excretions of calcium in feces and urine increased significantly in a dose response related pattern.And calcium contents of bone were significantly lower in the group exposed to 200?mg/L cadmium in drinking water than in the control group.Urinary β\-2 MG was significantly higher in cadmium exposed groups.Meanwhile urinary β\-2 MG positively related to total excretions of calcium in 24 hours.Conclusion The results indicated that cadmium could inhibit calcium metabolisms by increasing the excretions of calcium in feces and urine,which probably resulted in significant calcium declines in bone.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot