Title: Renal, Hepatic and Splenic Biotoxicity of Cadmium Sulphate in the Wistar Rats
Abstract: Heavy metals (lead, mercury and cadmium) cause problems of public health. Studies undertaken in Cote d'Ivoire within the framework of the environmental monitoring made it possible to apprehend the state of the cadmium pollution of the sediments, of the market garden grounds. Six (6) batches of rats Wistar males and females were made up. These rats were contaminated with cadmium sulfate by daily during 30 days with various proportion respectively 4; 5; 6.66; 10 and 20 mg/kg body weight (bw). The rats were weighed each week. At the end of the experiment, total blood was used for the hemogramm when the serum was used for proportioning of the enzymes and of the substrates using Cobas C311 ROCHE HITACHI. Work completed made it possible to determine the LD 50 of cadmium sulfate which is of 200 mg/kg bw. The weight of the rats of the batches treated with cadmium decreased significantly compared to the batch untreated (control). Transaminases, creatinine and the urea were increased significantly (p<0.05) when the bilirubin and cholesterol were decreased at the two sexes. However, the effect on cholesterol is not significant. Cadmium caused liver and kidney dysfunction and it decreased the weight of rats of both sexes.