Title: The DTI study of white matter fractional anisotropy in the first-episode patients with paranoid schizophrenia
Abstract: Objective To evaluate the fractional anisotropy of white matter fibers in some regions of interest (ROI) in the brain of the first-episode patients with paranoid schizophrenia and to provide further evidence for the disconnection hypothesis of schizophrenia.Methods Twenty first-episode patients with paranoid schizophrenia and twenty health controls paired with sex,age (±3 years old) and education were scanned by multi-vowel proton MR and diffusion tensor imaging.The spectra were obtained from a 1.5 T MR scanner by PRESS sequence with TR/TE of 1000/144ms.The fractional anisotropy (FA) was measured in 21 regions of interest.Results The mean values of FA of the bilateral frontal lobe,bilateral anterior limb of internal capsule,bilateral external capsule,left temporal lobe,left lap of internal capsule and lap of corpus callosum in the patients group were significant lower than those in the health control group (P0.05).The value of FA was no significant difference between the bilateral frontal lobe in the patient group (P0.05),whereas The value of FA was higher in the left frontal lobe than in the right frontal lobe (P0.05).The values of FA of the lap and posterior limb of internal capsule in the patient group were higher in the left hemisphere than in the right hemisphere,whereas The values of FA of the lap and posterior limb of internal capsule in health control group were higher in the right hemisphere than in the left hemisphere (P0.05).The value of FA in the external capsule in the both groups were lower in the right hemisphere than the left hemisphere (P0.05).Conclusions Patients with first-episode paranoid schizophrenia have significant reduction of white matter fractional anisotropy in multiple brain regions,particularly in the circuit loop of frontal lobe-subcortex.In addition,the normal leftright lateralization is absent or reversed in patients,which supports the disconnection hypothesis of schizophrenia.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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